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Art. -Nr.: HY-182542

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SOAT-IN-3

SOAT-IN-3 is a selective inhibitor of sodium-dependent organic anion transporter (SOAT/SLC10A6). SOAT-IN-3 reduces intracellular estradiol synthesis, the process of dehydroepiandrosterone (DHEA) production from DHEAS, and DHEAS-induced cancer cell proliferation. SOAT-IN-3 shows no cytotoxicity against breast cancer cells at the tested concentrations. SOAT-IN-3 can be used in the research of breast cancer.

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CAS. Nr.: 3056728-00-5
Formel: C₁₇H₁₁Cl₂N₃O₅S₂
Molecular Weight:472.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

SOAT-IN-3 Chemical Structure

CAS. Nr.: 3056728-00-5

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

SOAT-IN-3 (compound 24) (10 μM; 5 min preincubation) potently inhibits sodium-dependent SOAT-mediated [³H]DHEAS uptake in MCF-7_SOAT breast cancer cells^[1].
SOAT-IN-3 (10 μM; 10 min preincubation) completely inhibits DHEAS-induced proliferation in MCF-7_SOAT breast cancer cells, and no cytotoxic effect is observed when it is used alone^[1].
SOAT-IN-3 (10 μM; 10 min preincubation) significantly reduces the levels of DHEA and estradiol generated from DHEAS in MCF-7_SOAT breast cancer cells^[1].
SOAT-IN-3 potently inhibits SOAT-mediated DHEAS transport in SOAT-transfected HEK293 cells, with an IC₅₀ of 0.6 μM^[1].
SOAT-IN-3 (0.1-10 μM; 24 h) exhibits no cytotoxicity in MCF-7_SOAT or MCF-7_FRT breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

SOAT-overexpressing MCF-7 breast cancer cells (MCF-7_SOAT), control MCF-7_FRT cells
Concentration:

0.1-10 μM
Incubation Time:

24 h
Result:

Did not induce LDH release in either MCF-7_SOAT or MCF-7_FRT cells, indicating no cytotoxicity at these concentrations.

Chemical Information

CAS. Nr. 3056728-00-5
Molecular Weight 472.32
Formel C₁₇H₁₁Cl₂N₃O₅S₂
SMILES

O=S(C1=CC=CC([N+]([O-])=O)=C1)(NC2=C(C(NC3=CC(Cl)=C(Cl)C=C3)=O)SC=C2)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Karakus E, et al. Novel SOAT inhibitors block DHEAS transport and suppress proliferation in MCF-7 breast cancer cells. Sci Rep. 2026;16(1):12016. Published 2026 Apr 10. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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