STAD 2
Based on 1 publication(s) in Google Scholar
STAD 2 is a potent and selective disruptor of PKA-RII, with a Kd of 6.2 nM. STAD 2 disrupts interactions between PKA and AKAP in an isoform-selective manner. STAD 2 displays antimalarial activity through a PKA-independent mechanism.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.55%
- CAS. Nr.: 1542100-77-5
- Formel: C102H182N24O22
- Molecular Weight:2096.68
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Speicherung:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) STAD 2
More
Biologische Aktivität
PKA-RII[1]
Chemical Information
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CAS. Nr. 1542100-77-5
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Appearance Solid
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Molecular Weight 2096.68
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Formel C102H182N24O22
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Color White to off-white
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Sequence
{PEG3}-Lys-Lys-Leu-Ala-Lys-Phe-Leu-Val-Ser-{Aaa}-Ala-Leu-Lys-{Aaa}-Ala-Leu-Lys (Covalent bridge:Aaa10-Aaa14)
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Sequence Shortening
{PEG3}-KKLAKFLVS{Aaa}ALK{Aaa}ALK (Covalent bridge:Aaa10-Aaa14)
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur Heart J
Targeting P2Y14R alleviates platelet-induced NET formation and venous thrombosis through PKA/AKAP13/RhoA axis. [Abstract]2025 Oct 27:ehaf836. PMID: 41143464
Lösungsmittel & Löslichkeit
DMSO : ≥ 100 mg/mL (47.69 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Wang Y, et, al. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem Biol. 2014 Mar 21;9(3):635-42. [Content Brief]
[2]. Flaherty BR, et, al. The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. PLoS One. 2015 May 26;10(5):e0129239. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.4769 mL | 2.3847 mL | 4.7694 mL | 11.9236 mL |
| 5 mM | 0.0954 mL | 0.4769 mL | 0.9539 mL | 2.3847 mL | |
| 10 mM | 0.0477 mL | 0.2385 mL | 0.4769 mL | 1.1924 mL | |
| 15 mM | 0.0318 mL | 0.1590 mL | 0.3180 mL | 0.7949 mL | |
| 20 mM | 0.0238 mL | 0.1192 mL | 0.2385 mL | 0.5962 mL | |
| 25 mM | 0.0191 mL | 0.0954 mL | 0.1908 mL | 0.4769 mL | |
| 30 mM | 0.0159 mL | 0.0795 mL | 0.1590 mL | 0.3975 mL | |
| 40 mM | 0.0119 mL | 0.0596 mL | 0.1192 mL | 0.2981 mL |
STAD 2 Related Classifications
HY-P2261 Related Classifications
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