Sulfonadyn-47
Sulfonadyn-47 is a GTP-competitive dynamin I (dynI) inhibitor that targets the active site in the GTPase domain of dynamin I, with IC50 values of 3.5 μM against dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays. Sulfonadyn-47 increases seizure threshold. Sulfonadyn-47 can be used the study for the seizure.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3064686-59-2
- Formel: C22H23BrN2O2S
- Molecular Weight:459.40
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Sulfonadyn-47 shows inhibitory activity against dynI with IC50 values of 3.5 μM for dynI, 27.3 μM in clathrin-mediated endocytosis (CME) assays, and 12.3 μM in synaptic vesicle endocytosis (SVE) assays[1].
Sulfonadyn-47 (80 μM) has no effect on glutamate release in the synaptosomes [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Valproate induced 6 Hz acute seizures mouse model
-
Dosage:10, 30, 60 mg/kg
-
Administration:i.p. 30 min before stimulation
-
Result:Increased seizure threshold at doses of 30 and 60 mg/kg dose-dependently, with the threshold for the 60 mg/kg dose being equivalent to that to induce seizures in 50% of mice given 400 mg/kg of valproate.
Chemical Information
-
CAS. Nr. 3064686-59-2
-
Molecular Weight 459.40
-
Formel C22H23BrN2O2S
-
SMILES
BrC1=CC=C(C=C1)/C=C/CNCCCNS(=O)(C2=C3C=CC=CC3=CC=C2)=O
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Sulfonadyn-47 Related Classifications
HY-172531 Related Classifications
Powered by Bioz