TB-212
TB-212 is a potent, orally active anti-tuberculosis agent. TB-212 exhibits activity against both drug-susceptible and drug-resistant Mycobacterium tuberculosis strains, with favorable safety profiles. TB-212 is applicable to the research of tuberculosis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 3104768-44-4
- Formel: C24H30F3N5O4
- Molecular Weight:509.52
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
TB-212 potently inhibits Mycobacterium tuberculosis H37Ra with an MIC50 of 0.2 ng/mL[1].
TB-212 (Varying concentrations; 72 h) exhibits low cytotoxicity with an IC50 of 19.56 μM against HepG2 cells, IC50 >30 μM against Vero cells, and IC50 >50 μM against A549 cells[1].
TB-212 (5-45 min) has moderate metabolic stability in human liver microsomes (T1/2 = 23.71 min) and mouse liver microsomes (T1/2 = 26.77 min)[1].
TB-212 potently inhibits Mycobacterium tuberculosis H37Rv (MIC = 4 ng/mL) and drug-resistant clinical isolates (MIC range = 8-32 ng/mL), demonstrating efficacy against both drug-sensitive and drug-resistant strains[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (female, 5-6 weeks old)[1]
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Dosage:30 mg/kg; 150 mg/kg
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Administration:p.o.; daily; 5 days
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Result:Reduced relative light unit (RLU) values compared to the CMCNa negative control at both 30 mg/kg and 150 mg/kg doses.
Chemical Information
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CAS. Nr. 3104768-44-4
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Molecular Weight 509.52
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Formel C24H30F3N5O4
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SMILES
FC(F)(F)OC1=CC=C(C=C1)CN(CC2)CCC32CCN(C[C@@]4(C)CN5C(O4)=NC([N+]([O-])=O)=C5)CC3
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TB-212 Related Classifications
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