Terbufibrol (Standard)
Terbufibrol (Standard) is the analytical standard of Terbufibrol (HY-101812). This product is intended for research and analytical applications. Terbufibrol is an orally active lipid-lowering agent. Terbufibrol inhibits hepatic Cholesterol 7 alpha-hydroxylase. Terbufibrol blocks a step between Acetate and HMG-CoA in the hepatic cholesterol synthesis process. Terbufibrol reduces serum total cholesterol, HDL, LDL, lipoprotein levels, and the cholesterol/phospholipid ratio, with dose- and sex-dependent changes in lipoprotein components. Terbufibrol exerts sustained cholesterol-lowering activity in baboons and rats. Terbufibrol can be used in research related to hypercholesterolemia.
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- CAS. Nr.: 56488-59-6
- Formel: C20H24O5
- Molecular Weight:344.40
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Product Information
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Chemical Information
- Reinheit & Dokumentation
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Help & FAQs
Product Information
Information
Anwendung
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS. Nr. 56488-59-6
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Molecular Weight 344.40
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Formel C20H24O5
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SMILES
O=C(O)C1=CC=C(OCC(O)COC2=CC=C(C(C)(C)C)C=C2)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Howard AN, et al. The hypocholesterolemic effect of terbufibrol and other drugs in normal and hypercholesterolemic baboons. Atherosclerosis. 1979 Apr;32(4):367-80. [Content Brief]
[2]. Löser R, et al. Mode of action of terbufibrol (INN) a hypolipidemic agent on rat liver sterol synthesis. Artery. 1982;10(3):180-92. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Terbufibrol (Standard) Related Classifications
HY-101812R Related Classifications
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Keywords
- Terbufibrol (Standard)
- 56488-59-6
- Reference Standards
- Apolipoprotein
- LDLR
- Cytochrome P450
- hepatic cholesterol 7α-hydroxylase
- rats
- cytosols
- acetate
- baboons
- HPF-diet induced endogenous hypercholesterolemic male baboons
- hypercholesterolemia
- HMG-CoA
- rat liver
- HC-diet induced exogenous hypercholesterolemic male baboons
- Inhibitor
- inhibitor
- inhibit