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Art. -Nr.: HY-131374

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TN14003

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 368874-31-1
Formel: C₉₀H₁₄₁N₃₃O₁₈S₂
Molecular Weight:2037.42

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TN14003 Chemical Structure

CAS. Nr.: 368874-31-1

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Preis

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

TN14003 is a CXCR4 inhibitor. TN14003 has antitumor activity^[1].

Alle CXCR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	CC₅₀	410 μM Compound: TN-14003	Cytotoxicity against MDA-MB-231 cells Cytotoxicity against MDA-MB-231 cells	[PMID: 17958344]
MDA-MB-231	IC₅₀	0.6 nM Compound: TN-14003	Inhibition of CXCR4 in MDA-MB-231 cells Inhibition of CXCR4 in MDA-MB-231 cells	[PMID: 17958344]

In Vivo

TN14003 (7.5 mg/kg, intraperitoneal injection, 5 days per week) inhibits HER2 tumor growth by reducingangiogenesis and myofibroblast content^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Subcutaneous Cell-Line-Derived Xenograft

Chemical Information

CAS. Nr. 368874-31-1
Molecular Weight 2037.42
Formel C₉₀H₁₄₁N₃₃O₁₈S₂
Sequence

Arg-Arg-{Ala-(2-Naph)}-Cys-Tyr-{Cit}-Lys-Lys-Pro-Tyr-Arg-{Cit}-Cys-Arg-NH2 (Disulfide bridge: Cys4-Cys13)
Sequence Shortening

RR-{Ala-(2-Naph)}CY-{Cit}-KKPYR-{Cit}-CR-NH2 (Disulfide bridge: Cys4-Cys13)
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (258 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Lefort S, et al. CXCR4 inhibitors could benefit to HER2 but not to triple-negative breast cancer patients. Oncogene. 2017 Mar 2;36(9):1211-1222. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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