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Tomligisiran

Tomligisiran is a siRNA in JNJ-3989 (JNJ-73763989). JNJ-3989 is comprised of 2 siRNAs (Daplusiran and Tomligisiran), that target hepatitis B virus (HBV) mRNAs for degradation, thereby inhibiting HBV replication.

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  • Tomligisiran Chemical Structure
    Tomligisiran Chemical Structure
CAS. Nr.: 2202789-48-6
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  • Tomligisiran Chemical Structure
    Tomligisiran Chemical Structure RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-Cm-Gm-Cm-Um-Gm-Um-Am-Gm-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)A-Um-Am-Am-Am-Um-Um-Gm-Gm-Um-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-Cm-sp-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)G-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-Cm-sp-Gm) (1:1)
    1/16
  • RNA, ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-Cm-Gm-Cm-Um-Gm-Um-Am-Gm-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)A-Um-Am-Am-Am-Um-Um-Gm-Gm-Um-Am-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA), 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-Cm-sp-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)G-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Gm-Cm-sp-Gm) (1:1)