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Art. -Nr.: HY-189815

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TR79

TR79 is a mitochondrial ClpP protease activator with an EC₅₀ of 414.49 nM. TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation. TR79 can be used in research on mitochondria-related diseases (such as cancer and neurodegenerative diseases) and mitochondrial metabolic abnormalities.

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CAS. Nr.: 2365073-59-0
Formel: C₂₆H₂₆F₃N₅O₂
Molecular Weight:497.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

TR79 Chemical Structure

CAS. Nr.: 2365073-59-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
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Biologische Aktivität

Beschreibung

In Vitro

TR79 is a potent ClpP agonist, with an EC₅₀ of 414.49 nM in the ClpP activation assay^[1].
TR79 competitively occupies the ClpP binding site and attenuates MTP-B1-induced POLRMT degradation in cultured cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS. Nr. 2365073-59-0
Molecular Weight 497.51
Formel C₂₆H₂₆F₃N₅O₂
SMILES

NCCCN(C1=C(CN(CC2=CC=CC(C#N)=C2)CC1)C(N3CC4=CC=C(C(F)(F)F)C=C4)=O)C3=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Chen C, et al. Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond. JACS Au. 2026 Sep 28;6(9):5439-5454.

[2]. Yamada W, et al. Targeted protein degradation in the mitochondrial matrix and its application to chemical control of mitochondrial morphology. Chem Sci. 2024 Aug 28;15(36):14625-14634. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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