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Art. -Nr.: HY-N8395

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Tunicamycin V

(Synonyms: Tunicamycin A)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC₅₀ of 0.35?μM. Tunicamycin V has antibacterial activties.

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Reinheit: 95.0%
CAS. Nr.: 66054-36-2
Formel: C₃₉H₆₄N₄O₁₆
Molecular Weight:844.94

Speicherung:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Tunicamycin V Chemical Structure

CAS. Nr.: 66054-36-2

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (2)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 0.35 μM (phospho-N-acetylmuramyl-pentapeptide transferase (MraY))^[1]

In Vitro

Tunicamycins are nucleoside natural products isolated from the fermentation broths of Streptomyces lysosuperficus in 1971 and exhibit a variety of biological properties including antibacterial, antiviral, antifungal, and antitumor activities. Tunicamycins strongly inhibit UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase, the enzyme responsible for the first N-acetylglucosamination of the N-linked glycopeptide in endothelial reticulum (ER)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 66054-36-2
Appearance Solid
Molecular Weight 844.94
Formel C₃₉H₆₄N₄O₁₆
Color White to off-white
SMILES

O[C@H]1[C@@H](O)[C@@H](CC[C@H]([C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=CC(NC3=O)=O)O2)O)O[C@@H](O[C@@H]4[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@@H]1NC(/C=C/CCCCCCCCCC(C)C)=O
Synonyms

Tunicamycin A
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
Streptomyces xinghaiensis SCSIO S15077
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

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Journal Impact Factor

Cancer Lett

Pharmacological suppression of HHLA2 glycosylation restores anti-tumor immunity in colorectal cancer. [Abstract]

2024 May 1:589:216819. PMID: 38522775
Cancer Lett

Induction of EnR stress by Melatonin enhances the cytotoxic effect of Lapatinib in HER2-positive breast cancer. [Abstract]

2021 Oct 10:518:82-93. PMID: 34153400

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
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- Italian - IT (251 KB)
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- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Kazuki Yamamoto, et al. Structural requirement of tunicamycin V for MraY inhibition. Bioorg Med Chem. 2019 Apr 15;27(8):1714-1719. [Content Brief]

[2]. Kazuki Yamamoto, et al. Total Synthesis of Tunicamycin V. Org Lett. 2018 Jan 5;20(1):256-259. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Tunicamycin V

2 Cited Publications

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Biologische Aktivität
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- In Vitro
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Publications (2)
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Tunicamycin V

Publications Citing Use of MedChemExpress (MCE) Tunicamycin V

Biologische Aktivität

Chemical Information

Publications (2)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Tunicamycin V Related Classifications

Art. -Nr.: HY-N8395