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Art. -Nr.: HY-153942

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USP7-IN-12

USP7-IN-12 (compound 1) is a potent and orally active Usp7 inhibitor with an IC₅₀ value of 3.67 nM. USP7-IN-12 shows antiproliferative activity.

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CAS. Nr.: 2763698-01-5
Formel: C₂₉H₂₈ClFN₄O₂S
Molecular Weight:551.07

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

USP7-IN-12 Chemical Structure

CAS. Nr.: 2763698-01-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

USP7-IN-12 (compound 1) is a potent and orally active Usp7 inhibitor with an IC₅₀ value of 3.67 nM. USP7-IN-12 shows antiproliferative activity^[1].

IC₅₀ & Target^[1]

USP7

3.67 nM (IC₅₀)

Alle Deubiquitinase Isoform-spezifische Produkte anzeigen :

In Vitro

USP7-IN-12 (compound 1) (72 h) shows antiproliferative activity with an IC₅₀ value of 69.5 nM for RS4;11 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

USP7-IN-12 (5 mg/kg; p.o.) shows good pharmacokinetic data with T_1/2 of 3.68 h, T_max of 3.33 h, C_max of 330 ng/mL and AUC0-inf OF 2014 hr*ng/mL IN male SD rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 2763698-01-5
Molecular Weight 551.07
Formel C₂₉H₂₈ClFN₄O₂S
SMILES

O=C1N(CC2=CC3=NC=CC(C4=CC(Cl)=CC5=C4N(CC6(CCNCC6)F)C=C5)=C3S2)C(C7C1C7(C)C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Deng Hou, et al. Usp7 inhibitor. WO2022048498A1.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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USP7-IN-12

Alle Deubiquitinase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

USP7-IN-12 Related Classifications

HY-153942 Related Classifications