Art. -Nr.: HY-134454

Z-Pro-Pro-CHO

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Z-Pro-Pro-CHO is a potent inhibitor of prolyl oligopeptidase (POP), with extremely high affinity for human prolyl oligopeptidase (HsPOP) (IC₅₀=0.012 μM), and it also effectively inhibits the activity of Schistosoma mansoni prolyl oligopeptidase (SmPOP) (IC₅₀=0.16 μM). Z-Pro-Pro-CHO does not block the phosphorylation of ERK or the production of TNF-α or IFN-γ in immune cells from presensitized mice, nor does it induce harmful phenotypes in cultured Schistosoma mansoni schistosomula. Z-Pro-Pro-CHO only partially inhibits epithelial cell wound healing at extremely high concentrations. Z-Pro-Pro-CHO finds wide application in studies related to schistosomiasis.

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Reinheit: 98.03%
CAS. Nr.: 108708-25-4
Formel: C₁₈H₂₂N₂O₄
Molecular Weight:330.38

Speicherung:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Z-Pro-Pro-CHO Chemical Structure

CAS. Nr.: 108708-25-4

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Use of MCE Products

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Schistosome

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In Vitro

Z-Pro-Pro-CHO (100 μM; 20 min) does not inhibit Erk phosphorylation in SIINFEKL-restimulated splenocytes and lymph node cells from 6-day immunized OT-I cell-engrafted C57BL/6 mice^[1].
Z-Pro-Pro-CHO (100 μM; 20 min) does not block TNF-α or IFN-γ production by SIINFEKL-restimulated OT-I cells from 6-day immunized C57BL/6 mice^[1].
Z-Pro-Pro-CHO (>200 μM) partially inhibits wound closure in MDCK epithelial cells only at concentrations >200 μM, which are near cytotoxic levels and far above its potent POP inhibitory potency^[2].
Z-Pro-Pro-CHO selectively inhibits prolyl oligopeptidase activity in Schistosoma mansoni egg, miracidia, newly transformed schistosomula, and adult homogenates, confirming the activity is due to SmPOP^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 108708-25-4
Appearance Solid
Molecular Weight 330.38
Formel C₁₈H₂₂N₂O₄
Color Off-white to light yellow
Sequence

Z-Pro-Pro-CHO
Sequence Shortening

Z-PP-CHO
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (302.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0268 mL

15.1341 mL

30.2682 mL

5 mM

0.6054 mL

3.0268 mL

6.0536 mL

10 mM

0.3027 mL

1.5134 mL

3.0268 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Ménoret A, et al. The oxazolidinone derivative locostatin induces cytokine appeasement. J Immunol. 2009;183(11):7489-7496. [Content Brief]

[2]. Zhu S, et al. A chemical inhibitor reveals the role of Raf kinase inhibitor protein in cell migration. Chem Biol. 2005;12(9):981-991. [Content Brief]

[3]. Fajtová P, et al. Prolyl Oligopeptidase from the Blood Fluke Schistosoma mansoni: From Functional Analysis to Anti-schistosomal Inhibitors. PLoS Negl Trop Dis. 2015;9(6):e0003827. Published 2015 Jun 3. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0268 mL	15.1341 mL	30.2682 mL	75.6704 mL
	5 mM	0.6054 mL	3.0268 mL	6.0536 mL	15.1341 mL
	10 mM	0.3027 mL	1.5134 mL	3.0268 mL	7.5670 mL
	15 mM	0.2018 mL	1.0089 mL	2.0179 mL	5.0447 mL
	20 mM	0.1513 mL	0.7567 mL	1.5134 mL	3.7835 mL
	25 mM	0.1211 mL	0.6054 mL	1.2107 mL	3.0268 mL
	30 mM	0.1009 mL	0.5045 mL	1.0089 mL	2.5223 mL
	40 mM	0.0757 mL	0.3784 mL	0.7567 mL	1.8918 mL
	50 mM	0.0605 mL	0.3027 mL	0.6054 mL	1.5134 mL
	60 mM	0.0504 mL	0.2522 mL	0.5045 mL	1.2612 mL
	80 mM	0.0378 mL	0.1892 mL	0.3784 mL	0.9459 mL
	100 mM	0.0303 mL	0.1513 mL	0.3027 mL	0.7567 mL

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Z-Pro-Pro-CHO

Anti-Infection Compound Library

Metabolism/Protease Compound Library

Antiparasitic Compound library

Peptide Library

Human Metabolite Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Peptide Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Z-Pro-Pro-CHO

Anti-Infection Compound Library

Metabolism/Protease Compound Library

Antiparasitic Compound library

Peptide Library

Human Metabolite Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Cysteine Targeted Covalent Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Peptide Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Mass Spectrometry Human Metabolite Library

Alle Parasite Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Z-Pro-Pro-CHO Related Classifications

Art. -Nr.: HY-134454