Z6466608628
Z6466608628 is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 functionally recruits PPIL4 to CRBN, induces CRL4CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 can be used for the research of intracranial aneurysms.
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- CAS. Nr.: 2869183-63-9
- Formel: C23H24N4O3
- Molecular Weight:404.46
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Z6466608628 (10 nM-100 μM; 1 h) potently induces ternary complex formation between recombinant human CRBN-DDB1ΔB and human PPIL4 with an EC50 of 0.34 μM[1].
Z6466608628 (1.66-3.33 μM; 1 h) selectively recruits human PPIL4 and its binding partner DHX40 to recombinant human CRBN-DDB1ΔB in Kelly cell lysate[1].
Z6466608628 (1 μM; 5 h) induces selective, modest downregulation of PPIL4 in MOLT4 cells[1].
Z6466608628 (0.1-10 μM; 5 H) causes dose-dependent depletion of PPIL4 protein in MOLT4 cells, with incomplete degradation observed at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2869183-63-9
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Molecular Weight 404.46
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Formel C23H24N4O3
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SMILES
O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3C4=CC=C(C=C4)N5CCNCC5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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