Actoxumab
Based on 1 Customer Validation
Actoxumab (Anti-C. difficile Toxin A Recombinant Antibody) is a antitoxin antibody against C. difficile toxin A by neutralizing TcdA. Actoxumab prevents both the damage to the gut wall and the inflammatory response, which are associated with C. difficile. Actoxumab has synergy effect with Bezlotoxumab (HY-P9929) targeting TcdB.
For research use only. We do not sell to patients.
- Purity : 99.52%
- CAS No.: 1245634-25-6
- Molecular Weight:145 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Clostridioides difficile
IC50 & Target
ToxA
In Vitro
Actoxumab (10 mg/kg WT or N297Q mutant (N297Q) actoxumab-bezlotoxumab; 2 h plus 24 h) significantly inhibits cell rounding activity in Vero cells under 2 ng/mL TcdA treatment[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Actoxumab shows a synergy with Bezlotoxumab, and (combination dosage of 3, 30, 300 μg/mouse; i.p.; single dose) prevents both epithelial damage and inflammatory disease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Murine C. difficile infection model in CD1 and C57BL/6 mice (6-8 weeks old)[1]
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Dosage:Combination dosage of 3, 30, 300 μg/mouse; or ~0.1, 1, and 10 mg/kg
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Administration:Intraperitoneal injection; single dose; 1 hour before 25 ng TcdA or 25 ng TcdB challenge
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Result:Protected with Bezlotoxumab, against systemic and intestinal toxin challenge in mice.
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Animal Model:Ileal loop model in CD1 and C57BL/6 mice (6-8 weeks old)[1]
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Dosage:50 mg/kg; or combined with 50 mg/kg Bezlotoxumab
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Administration:Intraperitoneal injection; single dose
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Result:Significantly reduced fluid accumulation in toxin-challenged mice (109.4 mg/cm).
Accession
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 1245634-25-6
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Appearance Liquid
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Molecular Weight 145 kDa
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Color Colorless to light yellow
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SMILES
[Actoxumab]
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Synonyms
Anti-C. difficile Toxin A Recombinant Antibody
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (260 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Actoxumab Related Classifications
HY-P99277 Related Classifications
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