Fasinumab
Based on 1 Customer Validation
Fasinumab (REGN475) is a human IgG4 monoclonal antibody against nerve growth factor (NGF) that binds NGF and blocks its biological activity. Fasinumab is used in research on osteoarthritis and pain.
For research use only. We do not sell to patients.
- Purity : 98.11%
- CAS No.: 1190239-42-9
- Molecular Weight:144.9 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity
Human
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NGF |
In Vitro
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, adult, most experiments 10-16 weeks old)[3]
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Dosage:50 mg/kg
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Administration:s.c.; single administration; 3 days before intra-plantar NGF
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Result:Blocked NGF-induced thermal hyperalgesia.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG4 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow cytometric analysis of 1.5×106 SHSY5Y cells labeling Fasinumab (HY-P99195, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
Chemical Information
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CAS No. 1190239-42-9
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Appearance Liquid
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Molecular Weight 144.9 kDa
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Color Colorless to light yellow
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SMILES
[Fasinumab]
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Synonyms
REGN475; SAR-164877
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[3]. Somersan-Karakaya S, et al. Monoclonal antibodies against GFRα3 are efficacious against evoked hyperalgesic and allodynic responses in mouse join pain models but, one of these, REGN5069, was not effective against pain in a randomized, placebo-controlled clinical trial in patients with osteoarthritis pain. Neurobiol Pain. 2023 Jun 26;14:100136. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)