NINJ2 - ninjurin 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4815

About NINJ2

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:564,296-663,445 (from NCBI)

This gene has 6 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in lung (RPKM 12.3), bone marrow (RPKM 6.0) and 21 other tissues.

Summary

The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]

NINJ2 Products (4)

mRNA Protein Name
NM_001294345.2 NP_001281274.1 ninjurin-2 isoform 2
NM_001294346.2 NP_001281275.1 ninjurin-2 isoform 3
NM_001367996.1 NP_001354925.1 ninjurin-2 isoform 3
NM_016533.6 NP_057617.3 ninjurin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
NOT enables membrane destabilizing activity IDA
IDA: Inferred from direct assay
33472215 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in cytolysis IDA
IDA: Inferred from direct assay
33472215 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NINJ2 Protein Structure

Ninjurin

Ninjurin: Ninjurin (69 - 172)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

ninjurin-2

  • nerve injury-induced protein 2

NINJ2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NINJ2 Q9NZG7 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 IFNGR1 Homo sapiens P15260
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 IFNGR1 Homo sapiens P15260
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
NINJ2 Q9NZG7 VMA21 Homo sapiens Q3ZAQ7
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 VMA21 Homo sapiens Q3ZAQ7
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 GJA1 Homo sapiens P17302
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 GJA1 Homo sapiens P17302
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 ELOVL5 Homo sapiens Q9NYP7
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 ELOVL5 Homo sapiens Q9NYP7
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 KCNJ6 Homo sapiens P48051
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 KCNJ6 Homo sapiens P48051
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 MR1 Homo sapiens Q95460-2
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 MR1 Homo sapiens Q95460-2
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TMPRSS2 Homo sapiens O15393-2
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMPRSS2 Homo sapiens O15393-2
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 RIC3 Homo sapiens Q7Z5B4-5
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 RIC3 Homo sapiens Q7Z5B4-5
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 ODF4 Homo sapiens Q2M2E3
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 ODF4 Homo sapiens Q2M2E3
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CEACAM3 Homo sapiens P40198
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CEACAM3 Homo sapiens P40198
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SLC66A1 Homo sapiens Q6ZP29-3
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 SLC66A1 Homo sapiens Q6ZP29-3
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra
NINJ2 Q9NZG7 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 LYPD5 Homo sapiens Q6UWN5
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 LYPD5 Homo sapiens Q6UWN5
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 EREG Homo sapiens O14944
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 EREG Homo sapiens O14944
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CHODL Homo sapiens Q9H9P2
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CHODL Homo sapiens Q9H9P2
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 IL3RA Homo sapiens P26951
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 IL3RA Homo sapiens P26951
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 PIGP Homo sapiens P57054
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 PIGP Homo sapiens P57054
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 BTNL9 Homo sapiens Q6UXG8-3
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 BTNL9 Homo sapiens Q6UXG8-3
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TM4SF20 Homo sapiens Q53R12
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TM4SF20 Homo sapiens Q53R12
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SLAMF8 Homo sapiens Q9P0V8
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 SLAMF8 Homo sapiens Q9P0V8
Validated Y2H
32296183
Intra
NINJ2 Q9NZG7 SLAMF8 Homo sapiens Q9P0V8
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 VSIG1 Homo sapiens Q86XK7
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 VSIG1 Homo sapiens Q86XK7
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 AMIGO1 Homo sapiens Q86WK6
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 AMIGO1 Homo sapiens Q86WK6
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TSPAN12 Homo sapiens O95859
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TSPAN12 Homo sapiens O95859
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CYBC1 Homo sapiens Q9BQA9
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CYBC1 Homo sapiens Q9BQA9
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 FCGRT Homo sapiens P55899
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 FCGRT Homo sapiens P55899
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CD69 Homo sapiens Q07108
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CD69 Homo sapiens Q07108
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 M6PR Homo sapiens P20645
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 M6PR Homo sapiens P20645
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TMEM101 Homo sapiens Q96IK0
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TMEM101 Homo sapiens Q96IK0
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 CLEC7A Homo sapiens Q9BXN2
Y2H Array
25416956
Intra
NINJ2 Q9NZG7 FCRL4 Homo sapiens Q96PJ5
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 FCRL4 Homo sapiens Q96PJ5
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 MMGT1 Homo sapiens Q8N4V1
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 MMGT1 Homo sapiens Q8N4V1
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
NINJ2 Q9NZG7 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMEM9 Homo sapiens Q9P0T7
Validated Y2H
32296183
Intra
NINJ2 Q9NZG7 TMEM9 Homo sapiens Q9P0T7
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMEM9 Homo sapiens Q9P0T7
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 ICAM3 Homo sapiens P32942
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 ICAM3 Homo sapiens P32942
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TMEM51 Homo sapiens Q9NW97
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
25416956
Intra
NINJ2 Q9NZG7 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
NINJ2 Q9NZG7 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
NINJ2 Q9NZG7 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
NINJ2 Q9NZG7 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 4

  • IBD4
Idiopathic Peripheral Autonomic Neuropathy
Acrocallosal Syndrome

  • ACLS

  • Schinzel Acrocallosal Syndrome

  • Joubert Syndrome 12

  • Schinzel Syndrome 1

  • Acrocallosal Syndrome, Schinzel Type

  • Hallux Duplication, Postaxial Polydactyly, And Absence Of Corpus Callosum

  • Acs

  • Absence Of Corpus Callosum With Unusual Facial Appearance, Mental Deficiency, Duplication Of The Halluces And Polydactyly

  • Hallux Duplication Postaxial Polydactyly And Absence Of Corpus Callosum

  • JBTS12

  • Acrocallosal Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09299 NINJ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NINJ2 VGNC VGNC:32079
Canis familiaris NINJ2 VGNC VGNC:43812
Felis catus NINJ2 VGNC VGNC:68496
Mus musculus NINJ2 MGD MGI:1352751
Rattus norvegicus NINJ2 RGD RGD:620552
Others NINJ2 NCBI