ERMP1 - endoplasmic reticulum metallopeptidase 1 Gene

Also Known as FXNA; KIAA1815; bA207C16.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79956

About ERMP1

Cytogenetic location: 9p24.1 Genomic coordinates (GRCh38): 9:5,784,572-5,867,091 (from NCBI)

This gene has 30 transcripts (splice variants) and 233 orthologues. Ubiquitous expression in thyroid (RPKM 22.8), kidney (RPKM 19.4) and 24 other tissues.

Summary

Predicted to enable metal ion binding activity and metalloexopeptidase activity. Involved in cellular response to oxidative stress. Acts upstream of or within endoplasmic reticulum unfolded protein response. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ERMP1 Products (2)

mRNA Protein Name
NM_001410952.1 NP_001397881.1 endoplasmic reticulum metallopeptidase 1 isoform 2
NM_024896.3 NP_079172.2 endoplasmic reticulum metallopeptidase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
27566589 GOA
acts upstream of or within endoplasmic reticulum unfolded protein response IMP
IMP: Inferred from mutant phenotype
27566589 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERMP1 Protein Structure

Peptidase_M28

Peptidase_M28: Peptidase family M28 (199 - 368)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 904 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum metallopeptidase 1

  • Felix-ina

ERMP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ERMP1 Q7Z2K6 SPAG4 Homo sapiens Q9NPE6
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 SPAG4 Homo sapiens Q9NPE6
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 SPAG4 Homo sapiens Q9NPE6
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 TMEM45A Homo sapiens Q9NWC5
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 TMEM45A Homo sapiens Q9NWC5
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 TMEM45A Homo sapiens Q9NWC5
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 HIBADH Homo sapiens P31937
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 HIBADH Homo sapiens P31937
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 BSCL2 Homo sapiens J3KQ12
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 BSCL2 Homo sapiens J3KQ12
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 CLEC2D Homo sapiens Q9UHP7-3
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 CLEC2D Homo sapiens Q9UHP7-3
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 CLEC2D Homo sapiens Q9UHP7-3
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 SLC22A23 Homo sapiens A1A5C7-2
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 SLC22A23 Homo sapiens A1A5C7-2
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 MR1 Homo sapiens Q95460-2
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 MR1 Homo sapiens Q95460-2
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 MR1 Homo sapiens Q95460-2
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 SLC13A4 Homo sapiens Q9UKG4
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 SLC13A4 Homo sapiens Q9UKG4
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 SLC13A4 Homo sapiens Q9UKG4
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 CD200R1 Homo sapiens Q8TD46-4
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 CD200R1 Homo sapiens Q8TD46-4
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 CD200R1 Homo sapiens Q8TD46-4
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 ATP1B4 Homo sapiens Q9UN42
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 ATP1B4 Homo sapiens Q9UN42
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 ATP1B4 Homo sapiens Q9UN42
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 RHCG Homo sapiens Q9UBD6
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 RHCG Homo sapiens Q9UBD6
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 RHCG Homo sapiens Q9UBD6
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 LYPD5 Homo sapiens Q6UWN5
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 LYPD5 Homo sapiens Q6UWN5
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 KCNN3 Homo sapiens Q9UGI6-2
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 KCNN3 Homo sapiens Q9UGI6-2
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 KCNN3 Homo sapiens Q9UGI6-2
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 ERVFRD-1 Homo sapiens P60508
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 ERVFRD-1 Homo sapiens P60508
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 CLDN9 Homo sapiens O95484
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 CLDN9 Homo sapiens O95484
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 CLDN5 Homo sapiens O00501
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 CLDN5 Homo sapiens O00501
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 HHLA2 Homo sapiens Q9UM44
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 HHLA2 Homo sapiens Q9UM44
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 HHLA2 Homo sapiens Q9UM44
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 SLC7A14 Homo sapiens Q8TBB6
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 SLC7A14 Homo sapiens Q8TBB6
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 SLC7A14 Homo sapiens Q8TBB6
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 PEX12 Homo sapiens O00623
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 PEX12 Homo sapiens O00623
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 IER3IP1 Homo sapiens Q9Y5U9
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 IER3IP1 Homo sapiens Q9Y5U9
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 IER3IP1 Homo sapiens Q9Y5U9
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
ERMP1 Q7Z2K6 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Intra
ERMP1 Q7Z2K6 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 KLRC1 Homo sapiens P26715
Y2H Array
32296183
Intra
ERMP1 Q7Z2K6 KLRC1 Homo sapiens P26715
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04506 ERMP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ERMP1 VGNC VGNC:72322
Felis catus ERMP1 VGNC VGNC:97421
Canis familiaris ERMP1 VGNC VGNC:40463
Bos taurus ERMP1 VGNC VGNC:28592
Mus musculus ERMP1 MGD MGI:106250
Rattus norvegicus ERMP1 RGD RGD:727831
Others ERMP1 NCBI