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Cat. No.: HY-P992534

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LEVI-04

LEVI-04 is a p75NTR-Fc fusion protein. LEVI-04 blocks and clears neurotrophins, binding excess NGF to block NGF activity, and binds NT-3 with high affinity to inhibit NT-3 activity. LEVI-04 inhibits NT-3-mediated TrkC receptor signaling and supplements endogenous p75NTR. LEVI-04 can be used in research on osteoarthritis and knee osteoarthritis.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LEVI-04 Chemical Structure

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Quantity

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Species Reactivity
- IC₅₀ & Target
- Target
- Conjugated
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Species Reactivity

Human

IC₅₀ & Target

^[1]

TrkC

All Trk Receptor Isoforms :

Target

NT-3

Conjugated

Unconjugated

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[LEVI-04]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Fedotcheva TA, et al. Current State of the Neurotrophin-Based Pharmaceutics in the Treatment of Neurodegenerative Diseases and Neuroinflammation. Medical sciences (Basel, Switzerland). 2025 Dec 29;14(1):15. [Content Brief]

[2]. Conaghan P G, et al. OA04 A randomised controlled Phase II trial of LEVI-04, a novel neurotrophin-3 inhibitor, in knee osteoarthritis demonstrates substantially improved pain and function without deleterious effects on joint structure[J]. Rheumatology, 2025, 64(Supplement_3): keaf142. 004.

[3]. Conaghan P G, et al. LEVI-04, A NOVEL NEUROTROPHIN-3 INHIBITOR, SUBSTANTIALLY IMPROVES PAIN AND FUNCTION IN PEOPLE WITH KNEE OSTEOARTHRITIS: A RANDOMISED CONTROLLED PHASE II TRIAL[J]. Osteoarthritis and Cartilage, 2025, 33: S65-S66.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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