MODAG-005
Based on 1 Customer Validation
MODAG-005 is a blood-brain barrier-permeable PET probe precursor for α-synuclein (α‑Syn) aggregates, with a Ki value of 0.4 nM and a Kd value of 0.2 nM. MODAG-005 specifically binds to high-affinity sites within the tubular cavity of α-synuclein fibrils, and exhibits selectivity over tau protein fibrils and β-amyloid (A1-42) fibrils. MODAG-005 is applicable to the research of multiple system atrophy and Parkinson's disease.
For research use only. We do not sell to patients.
- Purity : 98.36%
- CAS No.: 2648041-73-8
- Formula: C15H13BrN4
- Molecular Weight:329.19
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All α-synuclein Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
α-synuclein Aggregation 0.2 nM (Kd) |
MAO-B 0.8 μM (IC50) |
In Vitro
[3H]MODAG-005 exhibits subnanomolar binding affinity for recombinant human α-synuclein fibrils, shows 36-fold lower affinity for tau fibrils and over 100-fold lower affinity for Aβ1-42 fibrils, with an MAO-B IC50 of 0.8 μM and no other relevant off-target binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits specific, pathology-associated binding to intracellular α-synuclein aggregates in α-SynA30P transgenic mice[1].
[11C]MODAG-005 (intravenous administration; single bolus injection) exhibits favorable pharmacokinetic properties in healthy cynomolgus monkeys, including rapid brain uptake, rapid clearance, and detectable plasma metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2648041-73-8
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Appearance Solid
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Molecular Weight 329.19
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Formula C15H13BrN4
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Color Yellow to green
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SMILES
CNC1=CC=C(C=C1)C2=NNC(C3=CC=NC(Br)=C3)=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (379.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0378 mL | 15.1888 mL | 30.3776 mL | 75.9440 mL |
| 5 mM | 0.6076 mL | 3.0378 mL | 6.0755 mL | 15.1888 mL | |
| 10 mM | 0.3038 mL | 1.5189 mL | 3.0378 mL | 7.5944 mL | |
| 15 mM | 0.2025 mL | 1.0126 mL | 2.0252 mL | 5.0629 mL | |
| 20 mM | 0.1519 mL | 0.7594 mL | 1.5189 mL | 3.7972 mL | |
| 25 mM | 0.1215 mL | 0.6076 mL | 1.2151 mL | 3.0378 mL | |
| 30 mM | 0.1013 mL | 0.5063 mL | 1.0126 mL | 2.5315 mL | |
| 40 mM | 0.0759 mL | 0.3797 mL | 0.7594 mL | 1.8986 mL | |
| 50 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5189 mL | |
| 60 mM | 0.0506 mL | 0.2531 mL | 0.5063 mL | 1.2657 mL | |
| 80 mM | 0.0380 mL | 0.1899 mL | 0.3797 mL | 0.9493 mL | |
| 100 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.7594 mL |
MODAG-005 Related Classifications
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