7-Methoxyrosmanol
Based on 1 Customer Validation
7-Methoxyrosmanol (7-O-Methoxyrosmanol), a phenolic diterpene isolated from rosemary, suppresses the cAMP responsiveness of PEPCK and G6Pase promoters.
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- Pureté : 99.28%
- CAS No.: 113085-62-4
- Formule: C21H28O5
- Masse moléculaire:360.44
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
86.5 μM
Compound: 10
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Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
Cytotoxicity against human A549 cells assessed as growth inhibition by WST-8 assay
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[PMID: 24210499] |
| A549 | IC50 |
>60 μM
Compound: 8
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Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against human A549 cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| A549 | IC50 |
42.5 μM
Compound: 8
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Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against human A549 cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| HeLa | IC50 |
>60 μM
Compound: 8
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Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| HeLa | IC50 |
42.2 μM
Compound: 8
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Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| MCF7 | IC50 |
37.5 μM
Compound: 8
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Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| MCF7 | IC50 |
55.6 μM
Compound: 8
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Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against human sMCF7 cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| Vero | IC50 |
42.2 μM
Compound: 8
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Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells at lag phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
| Vero | IC50 |
47.2 μM
Compound: 8
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Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay
Cytotoxicity against african green monkey Vero cells at exponential phase of growth after 48 hrs by MTT assay
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[PMID: 19711987] |
Chemical Information
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CAS No. 113085-62-4
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Appearance Solid
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Masse moléculaire 360.44
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Formule C21H28O5
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Color White to off-white
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SMILES
O=C1[C@](C(C2=CC(C(C)C)=C3O)=C3O)(CCCC(C)4C)[C@@]4([H])[C@@H]([C@H]2OC)O1
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Synonyms
7-O-Methoxyrosmanol
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (277.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (6.94 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (276 KB)
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SDS (459 KB)
- English - EN (459 KB)
- Français - FR (459 KB)
- Deutsch - DE (459 KB)
- Norwegian - NO (459 KB)
- Español - ES (459 KB)
- Swedish - SV (459 KB)
- Italian - IT (459 KB)
- Korean - KR (459 KB)
- Portuguese - PT (459 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7744 mL | 13.8719 mL | 27.7439 mL | 69.3597 mL |
| 5 mM | 0.5549 mL | 2.7744 mL | 5.5488 mL | 13.8719 mL | |
| 10 mM | 0.2774 mL | 1.3872 mL | 2.7744 mL | 6.9360 mL | |
| 15 mM | 0.1850 mL | 0.9248 mL | 1.8496 mL | 4.6240 mL | |
| 20 mM | 0.1387 mL | 0.6936 mL | 1.3872 mL | 3.4680 mL | |
| 25 mM | 0.1110 mL | 0.5549 mL | 1.1098 mL | 2.7744 mL | |
| 30 mM | 0.0925 mL | 0.4624 mL | 0.9248 mL | 2.3120 mL | |
| 40 mM | 0.0694 mL | 0.3468 mL | 0.6936 mL | 1.7340 mL | |
| 50 mM | 0.0555 mL | 0.2774 mL | 0.5549 mL | 1.3872 mL | |
| 60 mM | 0.0462 mL | 0.2312 mL | 0.4624 mL | 1.1560 mL | |
| 80 mM | 0.0347 mL | 0.1734 mL | 0.3468 mL | 0.8670 mL | |
| 100 mM | 0.0277 mL | 0.1387 mL | 0.2774 mL | 0.6936 mL |
7-Methoxyrosmanol Related Classifications
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