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BMS-309403

29 Cited Publications
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Based on 29 publication(s) in Google Scholar

BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.

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  • Pureté: 99.91%
  • CAS No.: 300657-03-8
  • Formule: C31H26N2O3
  • Masse moléculaire:474.55
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • BMS-309403 Chemical Structure
    BMS-309403 Chemical Structure
  • Experimental Validation Results for BMS-309403
  • Experimental Validation Results for BMS-309403
  • Experimental Validation Results for BMS-309403
  • Experimental Validation Results for BMS-309403
  • Experimental Validation Results for BMS-309403
  • Experimental Validation Results for BMS-309403
CAS No.: 300657-03-8
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  • BMS-309403 Chemical Structure
    BMS-309403 Chemical Structure
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    BMS-309403 purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2023 Oct 28:575:216403. [Abstract]

    Customer Validation
     STAM mice were treated with small-molecule inhibitors targeting LPL (Orlistat, S+O), FABP4 (BMS309403 (15 mg/kg, ip, twice a week), S+B), or CPT1 (Etomoxir, S+E). Tumor burden was reduced in all inhibitor-treated groups compared to the STAM control group.

  • 1/16

    BMS-309403 purchased from MedChemExpress. Usage Cited in: Bone Res. 2022 Jun 22;10(1):45. [Abstract]

    Customer Validation
     The effect of FABP4 and M1-polarized macrophage supernatant on HUVECs, FLSs, and chondrocytes in vitro. Tube formation assay and quantification of HUVECs cultured with vehicle (C), rhFABP4 (P), rhFABP4 + BMS309403 (20 μmol/L, 1h) (PB). Scale bar: 100 µm.

  • 1/16

    BMS-309403 purchased from MedChemExpress. Usage Cited in: Bone Res. 2022 Jun 22;10(1):45. [Abstract]

    Customer Validation
     The effect of FABP4 and M1-polarized macrophage supernatant on HUVECs, FLSs, and chondrocytes in vitro. Tube formation assay and quantification of HUVECs cultured with vehicle (C), M1-polarized macrophage supernatant (S), or M1-polarized macrophage supernatant+BMS309403 (20 μmol/L, 1h) (SB) (n = 3 per group). Scale bar: 100 µm.

  • 1/16

    BMS-309403 purchased from MedChemExpress. Usage Cited in: Bone Res. 2022 Jun 22;10(1):45. [Abstract]

    Customer Validation
     Representative images and quantification of FABP4 immunohistochemical staining and coimmunostaining of FABP4 with F4/80 or NOS2 in the synovium of TSC1KO mice treated with vehicle, BMS309403 (5 mg/kg, ip, twice a week) or anagliptin for 4 weeks after AIA modeling (n = 10 per group). Scale bar: 12.5 µm and 100 µm.

  • 1/16

    BMS-309403 purchased from MedChemExpress. Usage Cited in: Bone Res. 2022 Jun 22;10(1):45. [Abstract]

    Customer Validation
     Representative images and quantification of FABP4 immunohistochemical staining and coimmunostaining of FABP4 with F4/80 or NOS2 in the synovium of TSC1KO mice treated with vehicle, BMS309403 (5 mg/kg, ip, twice a week) or anagliptin for 8 weeks after AIA modeling (n = 10 per group). Scale bar: 12.5 µm and 100 µm.

  • 1/16

    BMS-309403 purchased from MedChemExpress. Usage Cited in: Am J Cancer Res. 2019 Oct 1;9(10):2140-2155. [Abstract]

    Customer Validation
     FABP4 expression is up-regulated in the metastatic tumor sites. BALB/C nude mice are intrahepatic inoculation of 5 × 106 HepG2 cells followed by intraperitoneally injection with PBS or 25-HC (10 mg/kg) or 25-HC with BMS-309403 (45 mg/kg). At the end of the experiment, mice are sacrificed, the tumor tissues in the livers of the mice without metastasis, with abdominal metastasis and the metastatic tumor sites are extracted. The mRNA and protein expression of FABP4 is assessed by RT-qPCR

  • BMS-309403