AChE-IN-63
AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM). AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE); 1.342 μM (hBACE-1)). AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research.
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- CAS No.: 876685-78-8
- Formule: C18H19N5O
- Masse moléculaire:321.38
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
hAChE 0.103 μM (IC50) |
hBCHE 10 μM (IC50) |
In Vitro
AChE-IN-63 (5-20 μM; 48 h) inhibits Aβ1-42 aggregation in a concentration-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
AChE-IN-63 (p.o.; 5-20 mg/kg; single dose) improves learning and memory in cognitive dysfunction mice in the Scopolamine (HY-N0296) Y-Maze Model and demonstrates good antioxidant properties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Scopolamine Y-Maze Model [1]
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Dosage:5; 10 ;20 mg/kg
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Administration:p.o.; single dose
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Result:Showed significant improvement in spontaneous alternation behavior.
Reduced AChE and MDA levels and increased CAT levels.
Chemical Information
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CAS No. 876685-78-8
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Masse moléculaire 321.38
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Formule C18H19N5O
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SMILES
C1(C2=NN=C(O2)CN3CCN(CC3)C4=CC=CC=N4)=CC=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-63 Related Classifications
HY-158261 Related Classifications
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