AM12814
AM12814 is a potent and partial CB1 and CB2 agonist with Ki values of 0.7 nM and 3.4 nM. AM12814 can inhibit cAMP accumulation and recruitse β-arrestin 2. AM12814 exhibits cannabimimetic effects. AM12814 can be used for the research of neurological disease, suah as catalepsy.
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- CAS No.: 3054511-18-8
- Formule: C24H38F3NO2
- Masse moléculaire:429.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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rCB1-R 0.7 nM (Ki) |
hCB2-R 3.4 nM (Ki) |
AM12814 (Compound 12) binds to cannabinoid receptors with high affinity, with Ki values of 0.7 nM (rCB1) and 3.4 nM (hCB2)[1].
AM12814 (30 mins) inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in 3xHA-hCB1-CHO and 3xHA-hCB2-CHO cells with EC50 values of 8.75 nM and 22 nM[1].
AM12814 (90 mins) recruitses β-arrestin 2 in hCB1-DRx-CHO and hCB2-DRx-U2OS cells with EC50 values of 25 nM and 5.6 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CD1 mice[1]
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Dosage:0.3, 1 and 3 mg/kg
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Administration:Intraperitoneally injection
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Result:Increased immobility time in the ring test.
Reduced core body temperature.
Prolonged tail-flick latency in the hot water test.
Alleviated CFA (HY-153808)-induced mechanical hypersensitivity.
Chemical Information
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CAS No. 3054511-18-8
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Masse moléculaire 429.56
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Formule C24H38F3NO2
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SMILES
O=C(N[C@H](C)CO)CCC/C=C\C/C=C\C/C=C\[C@@H](C)/C=C\CCCCC(F)(F)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AM12814 Related Classifications
HY-178203 Related Classifications
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