Anticancer agent 342
Anticancer agent 342 is an anticancer compound with moderate antiproliferative activity against MCF7 cells. Anticancer agent 342 is applicable for cancer-related research.
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- CAS No.: 3099599-78-4
- Formule: C51H53F3N6O2S
- Masse moléculaire:871.07
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Activité biologique
Description
In Vitro
Anticancer agent 342 (III-244) exhibits moderate antiproliferative activity against MCF7 cells (GI50 = 0.05-0.5 μM)[1].
Anticancer agent 342 exhibits no significant antiproliferative activity against both ERα-overexpressing and non-overexpressing T-Rex 293 cells induced by Doxorubicin (HY-15142A) (GI50 > 2.5 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3099599-78-4
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Masse moléculaire 871.07
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Formule C51H53F3N6O2S
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SMILES
FC1=C(C(F)=CC(C2CCN(CC2)CC3(CCN(C4=CC=C(C5=N[C@@H](C)C6=NN=C(C)N6C7=C5C(C)=C(C)S7)C=C4)CC3)O)=C1)[C@@H]8[C@H](C9=CC=C(C=C9)F)CCC%10=CC(O)=CC=C%108
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 342 Related Classifications
HY-184929 Related Classifications
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