AP23464
AP23464 is an ATP-based inhibitor for Kit, that inhibits the phosphorylation of Kit wildtype and mutants, with IC50 of 5-85 nM. AP23464 inhibits the proliferation of Kit mutated cells (IC50 is 3-20 nM), arrests the cell cycle at G0/G1 phase, and induces apoptosis in Kit mutated cells.
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- CAS No.: 845895-51-4
- Formule: C26H30N5O2P
- Masse moléculaire:475.52
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
0.45 nM
Compound: 6; AP23464
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Inhibition of 6x-His-tagged human Src kinase domain (T250 to L536 residues) expressed in Sf9 cells incubated for 2 hrs in presence of biotinylated cdc2 peptide substrate by homogenous TR-FRET assay
Inhibition of 6x-His-tagged human Src kinase domain (T250 to L536 residues) expressed in Sf9 cells incubated for 2 hrs in presence of biotinylated cdc2 peptide substrate by homogenous TR-FRET assay
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[PMID: 27144831] |
Chemical Information
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CAS No. 845895-51-4
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Masse moléculaire 475.52
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Formule C26H30N5O2P
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SMILES
O=P(C)(C)C1=CC=C(NC2=NC(C3CCCC3)=NC4=C2N=CN4CCC5=CC(O)=CC=C5)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AP23464 Related Classifications
HY-10638 Related Classifications
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