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Cat. No.: HY-157010

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AP736

AP736 is a potent tyrosinase inhibitor (IC₅₀ = 0.9 μM) with anti-melanogenesis activity in normal human melanocytes (IC₅₀ = 0.11 μM). AP736 suppresses the expression of tyrosinase and TRP-1/2 by inhibiting the cAMP-PKA-CREB signalling axis, leading to reduced microphthalmia-associated transcription factor (MITF) transcripts and proteins. AP736 can be used for melanogenesis and hyperpigmentation research.

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CAS No.: 1365531-21-0
Formule: C₂₆H₃₁NO₅
Masse moléculaire:437.53

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

AP736 Chemical Structure

CAS No.: 1365531-21-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform PKA :

Cellular Effect

Cell Line	Type	Value	Description	References
B16	IC₅₀	1.1 μM Compound: 3c	Antimelanogenic activity in mouse B16 cells assessed as inhibition of melanogenesis Antimelanogenic activity in mouse B16 cells assessed as inhibition of melanogenesis	[PMID: 22300660]

Chemical Information

CAS No. 1365531-21-0
Masse moléculaire 437.53
Formule C₂₆H₃₁NO₅
SMILES

O=C(C1=C(OC)C=C(OC)C(C23CC4CC(C3)CC(C2)C4)=C1)NCC5=CC=C(C=C5O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Shin HJ, et al. Development and evaluation of topical formulations for a novel skin whitening agent (AP736) using Hansen solubility parameters and PEG-PCL polymers. Int J Pharm. 2018 Dec 1;552(1-2):251-257. [Content Brief]

[2]. Lee CS, et al. A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression. Exp Dermatol. 2013 Nov;22(11):762-4. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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