AVE1231
Based on 1 Customer Validation
AVE1231 (A293) is a dual-pore potassium channel TASK-1 inhibitor. AVE1231 blocks carbamoylcholine chloride (HY-B1208)-activated IKACh (IC50=8.4 μM). AVE1231 can be used in the study of arrhythmias and atrial fibrillation.
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- Pureté : 98.61%
- CAS No.: 767334-89-4
- Formule: C20H27N3O4S
- Masse moléculaire:405.51
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
Chemical Information
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CAS No. 767334-89-4
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Appearance Solid
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Masse moléculaire 405.51
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Formule C20H27N3O4S
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Color White to off-white
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SMILES
O=C(N[C@@H](C1=CC=C(OC)N=C1)CC)C2=CC=CC=C2NS(=O)(CCCC)=O
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Synonyms
A293
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
In Vitro:
DMSO : 125 mg/mL (308.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Wiedmann F, et al. Identification of the A293 (AVE1231) binding site in the cardiac two-pore-domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site[J]. Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG), 2019, 52(5). [Content Brief]
[2]. Wirth K J, et al. In vitro and in vivo effects of the atrial selective antiarrhythmic compound AVE1231[J]. Journal of cardiovascular pharmacology, 2007, 49(4): 197-206. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.4660 mL | 12.3302 mL | 24.6603 mL | 61.6508 mL |
| 5 mM | 0.4932 mL | 2.4660 mL | 4.9321 mL | 12.3302 mL | |
| 10 mM | 0.2466 mL | 1.2330 mL | 2.4660 mL | 6.1651 mL | |
| 15 mM | 0.1644 mL | 0.8220 mL | 1.6440 mL | 4.1101 mL | |
| 20 mM | 0.1233 mL | 0.6165 mL | 1.2330 mL | 3.0825 mL | |
| 25 mM | 0.0986 mL | 0.4932 mL | 0.9864 mL | 2.4660 mL | |
| 30 mM | 0.0822 mL | 0.4110 mL | 0.8220 mL | 2.0550 mL | |
| 40 mM | 0.0617 mL | 0.3083 mL | 0.6165 mL | 1.5413 mL | |
| 50 mM | 0.0493 mL | 0.2466 mL | 0.4932 mL | 1.2330 mL | |
| 60 mM | 0.0411 mL | 0.2055 mL | 0.4110 mL | 1.0275 mL | |
| 80 mM | 0.0308 mL | 0.1541 mL | 0.3083 mL | 0.7706 mL | |
| 100 mM | 0.0247 mL | 0.1233 mL | 0.2466 mL | 0.6165 mL |
AVE1231 Related Classifications
HY-126486 Related Classifications
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