CBD-TSC1
CBD-TSC1 is a reversible mixed-type inhibitor of human and mushroom tyrosinase, with an IC50 of 27.72 μM against mushroom tyrosinase. CBD-TSC1 interacts with both the free enzyme and the enzyme-substrate complex. CBD-TSC1 reduces intracellular reactive oxygen species (ROS) levels under oxidative stress as well as melanin content in zebrafish larvae.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C23H33N3O2S
- Masse moléculaire:415.59
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
mushroom Tyrosinase 27.72 μM (IC50) |
In Vitro
CBD-TSC1 (5-20 μM; 8-24 h) maintains the viability of G361 melanoma cells and HaCaT keratinocytes above 70%[1].
CBD-TSC1 (0.625-2.5 μM; 24 h pre-incubation) reduces H2O2-induced intracellular ROS in HaCaT and G361 cells, with a significant reduction at 2.5 μM[1].
CBD-TSC1 (0-75 μM) inhibits human tyrosinase diphenolase activity in G361 melanoma cell lysates with an IC50 of 34.47 μM and acts as a mixed-type inhibitor with a Ki of 26.96 μM[1].
CBD-TSC1 inhibits mushroom tyrosinase diphenolase with an IC50 of 27.72 μM, and as a reversible mixed-type inhibitor, it prolongs the lag phase of monophenolase by 5.5 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:G361 human melanoma cells and HaCaT human keratinocytes
-
Concentration:5 μM; 10 μM; 15 μM; 20 μM
-
Incubation Time:8, 12, 24 h
-
Result:At short-term exposure (up to 24 h), CBD-TSC1 was well tolerated in both cell lines, with viability remaining above 70% across all tested concentrations.
These findings indicate that CBD-TSC1 exhibited low acute cytotoxicity under the tested conditions and showed a comparable or slightly improved tolerability profile relative to CBD during the initial 12 h of exposure.
Chemical Information
-
Masse moléculaire 415.59
-
Formule C23H33N3O2S
-
SMILES
CC1=C[C@@H](C2=C(O)C=C(CCCCC)C(/C=N/NC(N)=S)=C2O)[C@H](C(C)=C)CC1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CBD-TSC1 Related Classifications
HY-189746 Related Classifications
Powered by Bioz