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Cat. No.: HY-16926R

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CK-666 (Standard)

CK-666 (Standard) is the analytical standard of CK-666 (HY-16926). This product is intended for research and analytical applications. CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC₅₀=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocK_ing movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation.

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CAS No.: 442633-00-3
Formule: C₁₈H₁₇FN₂O
Masse moléculaire:296.34

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CK-666 (Standard) Chemical Structure

CAS No.: 442633-00-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Product Information
- Information
- Application
Chemical Information
Pureté et documentation
Calculators
Help & FAQs
Classifications
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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 442633-00-3
Masse moléculaire 296.34
Formule C₁₈H₁₇FN₂O
SMILES

O=C(NCCC1=C(C)NC2=C1C=CC=C2)C3=CC=CC=C3F
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hetrick B, et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol. 2013 May 23;20(5):701-12. [Content Brief]

[2]. Brieuc P Perot, et al. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4⁺ T Lymphocytes. Front Cell Infect Microbiol. 2020 Feb 28;10:70. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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