CNP7
CNP7 is a covalent, selective HMGCS1 inhibitor. CNP7 reduces intracellular HMG-CoA levels. CNP7 induces global protein deisoprenylation. CNP7 exhibits a cell line-specific pattern of anticancer activity. CNP7 is applicable for cancer research.
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- Formule: C23H22N4O2
- Masse moléculaire:386.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
CNP7 (2.5-20 μM; 72 h) exhibits cell line-specific antiproliferative activity across 18 cancer and non-cancer cell lines, with resistance correlated to higher baseline and CNP7-induced HMGCS1 expression in HCT116, HT29, and HepG2 cells, and sensitivity observed in RPE1, MFE296, and MOLM13 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT116, HT29, HepG2, MCF7, PANC05.04, BT474, PC3, DU145, DLD1, Hela, U2OS, LnCap, RPE1, MFE296, MOLM13, JURKAT, MM.1S, SNU449
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Concentration:2.5-20 μM (cell viability assay); 1 μM (HMGCS1 expression analysis)
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Incubation Time:72 h (cell viability assay); 24 h (HMGCS1 expression analysis)
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Result:Exhibited cell line-specific antiproliferative activity.
Showed high viability across all tested concentrations in resistant cell lines (HCT116, HT29, HepG2).
Caused significant dose-dependent viability reduction in sensitive cell lines (RPE1, MFE296, MOLM13).
Induced similar sensitivity curves that saturated at earlier doses in MM1.S and SNU449 cells (compared to simvastatin).
Demonstrated higher sensitivity in RPE1 and MFE296 cells than simvastatin.
Revealed higher baseline HMGCS1 expression in resistant cell lines, which was further elevated by treatment.
Showed lower baseline HMGCS1 expression and less pronounced increase upon treatment in sensitive cell lines.
Chemical Information
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Masse moléculaire 386.45
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Formule C23H22N4O2
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SMILES
N#CN1C[C@@H](C(NCC2=CC=CC(C3=CC(C(NCC#C)=O)=CC=C3)=C2)=O)CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CNP7 Related Classifications
HY-183967 Related Classifications
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