CWHM-1552
CWHM-1552 is an orally efficacious inhibitor of P. falciparum with IC50s of 51 nM and 53 nM for 3D7 and Dd2 strain, respectively.
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- CAS No.: 2368253-58-9
- Formule: C22H27F2N3O
- Masse moléculaire:387.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
Description
IC50 & Target
IC50: 51 nM (3D7 strain) and 53 nM (Dd2 strain)[1]
In Vivo
CWHM-1552 (i.v. administration; 2 mg/kg/day for 48 hours) has respectable half-lives (2.7 h) and low clearance in mice[1].
CWHM-1552 has good pharmacokinetic properties and oral efficacy in a mouse model of malaria. CWHM-1552 has an in vivo ED90 of <10 mg/kg/day and ED99 of 30 mg/kg/day, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:P. chabaudi ASS infected Mice[1]
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Dosage:3, 10, 30 mg/kg
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Administration:Orally; daily for 4 days
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Result:Inhibited parasitemia at 99.9% at 30 mg/kg/day and 94% at 10 mg/kg/day.
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Animal Model:Male KM mice[1]
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Dosage:2 mg/kg
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Administration:I.v. administration; daily
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Result:Had respectable half-lives (2.7 h) and low clearance in mice.
Chemical Information
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CAS No. 2368253-58-9
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Masse moléculaire 387.47
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Formule C22H27F2N3O
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SMILES
CN(C)C1=CC=C(CC(N[C@@H]2CNC[C@H]2C3=CC=C(C(F)(C)F)C=C3)=O)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CWHM-1552 Related Classifications
HY-128354 Related Classifications
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