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Daplusiran

Daplusiran is a siRNA in JNJ-3989 (JNJ-73763989). JNJ-3989 is comprised of 2 siRNAs (Daplusiran and Tomligisiran), that target hepatitis B virus (HBV) mRNAs for degradation, thereby inhibiting HBV replication.

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  • CAS No.: 2202783-35-3
  • Formule: C492H650F12N163O310P43S7
  • Masse moléculaire:15591.60
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Daplusiran Chemical Structure
    Daplusiran Chemical Structure
CAS No.: 2202783-35-3
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  • Daplusiran Chemical Structure
    Daplusiran Chemical Structure RNA, (Am-sp-(2'-deoxy-2'-fluoro)G-sp-Am-sp-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Cm-Am-sp-Cm), complex with RNA ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Gm-Um-Gm-Gm-Am-Cm-Um-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Um-Cm-Am-Am-Um-Um-Um-Um-Cm-Um-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA) 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate] (1:1)
    1/16
  • RNA, (Am-sp-(2'-deoxy-2'-fluoro)G-sp-Am-sp-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)C-Cm-Am-sp-Cm), complex with RNA ([1'-de(6-amino-9H-purin-9-yl)]dA-(5'→5')-sp-Gm-Um-Gm-Gm-Am-Cm-Um-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-Um-Cm-Am-Am-Um-Um-Um-Um-Cm-Um-(3'→3')-sp-[1'-de(6-amino-9H-purin-9-yl)]dA) 3'-[O-[cis-4-[(3S,8S)-17-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-3,8-bis[[[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethyl]amino]carbonyl]-1,6,11-trioxo-15-oxa-2,7,12-triazaheptadec-1-yl]cyclohexyl] hydrogen phosphorothioate] (1:1)