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Cat. No.: HY-131923

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DAPM

DAPM is a Notch pathway inhibitor with anticancer activity and antiproliferative effects. DAPM effectively inhibits tubular adenoma development by inhibiting cell proliferation and inducing the expression of Krüppel-like factor 4 (KLF4) and p21 in human colon cancer cells.

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CAS No.: 208255-51-0
Formule: C₂₀H₂₀F₂N₂O₄
Masse moléculaire:390.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

DAPM Chemical Structure

CAS No.: 208255-51-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	12 μM Compound: DAPM	Antiproliferative activity against human HCT116 cells after 72 hrs by SYBR green dye based fluorescence assay Antiproliferative activity against human HCT116 cells after 72 hrs by SYBR green dye based fluorescence assay	[PMID: 30201292]

Chemical Information

CAS No. 208255-51-0
Masse moléculaire 390.38
Formule C₂₀H₂₀F₂N₂O₄
Sequence

N-[N-3,5-Difluorophenacetyl]-L-alanyl-S-phenylglycine methyl ester
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Miyamoto S, et al. Suppression of colon carcinogenesis by targeting Notch signaling. Carcinogenesis. 2013 Oct;34(10):2415-23. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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DAPM

High-Throughput Bioactive Compound Library

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

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DAPM Related Classifications

HY-131923 Related Classifications