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Cat. No.: HY-182529

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DHPS-IN-3

DHPS-IN-3 (Compound 26d) is a NAD-competitive DHPS inhibitor, with an IC₅₀ of 0.0092 μM at 14 μM NAD and an IC₅₀ of 0.069 μM at 250 μM NAD. DHPS-IN-3 is applicable for cancer research.

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CAS No.: 2470012-40-7
Formule: C₁₈H₂₃N₃OS
Masse moléculaire:329.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DHPS-IN-3 Chemical Structure

CAS No.: 2470012-40-7

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis :

In Vitro

DHPS-IN-3 potently inhibits deoxyhypusine synthase with an IC₅₀ of 0.0092 μM at 14 μM NAD, showing a NAD-competitive inhibitory profile^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	V_dss	CL_total	C_max	MRT	F
Mice^[1]	0.1 mg/kg	i.v.	8491 mL/kg	8965 mL/h/kg	/	/	/
Mice^[1]	1 mg/kg	p.o.	/	/	4.8 ng/mL	2.46 h	11.7 %

Chemical Information

CAS No. 2470012-40-7
Masse moléculaire 329.46
Formule C₁₈H₂₃N₃OS
SMILES

O=C1C2=C(CCN1[C@@H](CN)CC(C)C)C(C3=CN=CC=C3)=CS2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Tanaka Y, et al. New Series of Potent Allosteric Inhibitors of Deoxyhypusine Synthase. ACS Med Chem Lett. 2020;11(8):1645-1652. Published 2020 Jul 30. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références

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DHPS-IN-3

Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

DHPS-IN-3 Related Classifications

HY-182529 Related Classifications