DMG-PEG2000-ANG

DMG-PEG2000-ANG is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around the nanoparticle, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. ANG peptide: Targeting/functional ligand-ANG peptide (Angiopep-2) is a dual-target ligand that binds efficiently to low-density lipoprotein receptor-associated protein 1 (LRP1), mediating the nanocarrier's crossing of the blood-brain barrier (BBB) for targeted delivery to gliomas.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .