DSPE-PEG-Folate, MW 3350
Based on 1 Customer Validation
DSPE-PEG-Folate, MW 3350 is a PEG derivative containing folic acid. DSPE-PEG-Folate has a targeting effect and bind to folate receptors in cancer cells. DSPE-PEG-Folate form micelles/lipid bilayer and can be used to targeted drug delivery system research.
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- Pureté : 99.41%
- CAS No.: 1236288-25-7
- Formule: C65H114N11O16P
- Masse moléculaire:3400 (Average)
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Nanoparticles constructed with DSPE-PEG-Folate and anticancer drugs enter cells mainly through the endocytosis pathway mediated by FA receptors. The nanoparticles mainly accumulate in the cytoplasm, while the released drugs are distributed in the cytoplasm and nucleus, which can effectively deliver drugs to the nucleus to play a role. DSPE-PEG-Folate can increase the elimination half-life of the drug and prolong the blood circulation time[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 1236288-25-7
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Appearance Solid
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Masse moléculaire 3400 (Average)
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Formule C65H114N11O16P
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Color Yellow to brown
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SMILES
O=C(NCCOP(O)(OCC(COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(CCC(C(O)=O)NC(C1=CC=C(NCC(N=C23)=CNC3=NC(N)=NC2=O)C=C1)=O)=O.N.N.[n]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 50 mg/mL (ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Pureté et documentation
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Fiche technique (268 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Li Y, et, al. Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release. ACS Appl Mater Interfaces. 2015 Aug 19;7(32):17573-81. [Content Brief]
[2]. Werner ME, et, al. Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials. 2011 Nov;32(33):8548-54. [Content Brief]
[3]. Patlolla RR, et al. Folate-targeted etoposide-encapsulated lipid nanospheres. J Drug Target. 2008 May;16(4):269-75. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG-Folate, MW 3350 Related Classifications
HY-144009 Related Classifications
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