1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (DSPG) is an anionic (negatively charged) phospholipid. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is used to prepare lipid microbubbles as ultrasound contrast agents. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol can be used to construct liposomes as vaccine carriers for the treatment of atherosclerosis. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is applicable to the research of drug delivery and diagnostic preparations.
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- CAS No.: 217939-97-4
- Formule: C42H83O10P
- Masse moléculaire:779.08
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol forms part of the protein corona of liposomes and mediates the uptake by antigen-presenting cells[1].
When incorporated at a ratio of 60%, 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol enhances the stability of lipid-based microbubble shells, which helps prolong in vivo blood flow imaging duration and reduce hepatic uptake[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 217939-97-4
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Masse moléculaire 779.08
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Formule C42H83O10P
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SMILES
OCC(O)COP(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)(O)=O
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Synonyms
DSPG
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Benne N, et al. Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice. J Control Release. 2018;291:135-146. [Content Brief]
[2]. Maruyama T, et al. Effect of lipid shell composition in DSPG-based microbubbles on blood flow imaging with ultrasonography. Int J Pharm. 2020;590:119886. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol Related Classifications
HY-148601 Related Classifications
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