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Cat. No.: HY-188043

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EC216

Name: EC216
Brand: MedChemExpress
SKU: HY-188043
Availability: PreOrder

(Synonyms: Pte-Cys-ss-DAVLBH)

EC216 is a folate receptor (FR) targeted conjugate that competes for binding at the FR site, with a relative binding affinity of 0.046. EC216 is applicable to studies related to folate receptor-targeted delivery and vinca alkaloid cytotoxins.

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CAS No.: 926623-28-1
Formule: C₆₃H₇₅N₁₃O₁₃S₂
Masse moléculaire:1286.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

EC216 Chemical Structure

CAS No.: 926623-28-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Folate Receptor (FR) :

FR-α

In Vitro

EC216 (1 h) exhibits 21.7-fold weaker binding affinity than folic acid for folate receptors on adherent FR-positive human nasopharyngeal KB cells, with a relative affinity of 0.046^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 926623-28-1
Masse moléculaire 1286.48
Formule C₆₃H₇₅N₁₃O₁₃S₂
SMILES

CC[C@@]12[C@@]3([H])[C@@]4(CCN3CC=C2)C5=CC([C@@]6(C7=C(CC[N@@]8C[C@](C[C@](O)(C8)CC)([H])C6)C9=CC=CC=C9N7)C(OC)=O)=C(OC)C=C5N([C@@]4([H])[C@](O)([C@@H]1O)C(NNC(OCCSSC[C@@H](C(O)=O)NC(C%10=CC=C(C=C%10)NCC(N=C%11%12)=CNC%11=NC(N)=NC%12=O)=O)=O)=O)C
Synonyms

Pte-Cys-ss-DAVLBH
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Leamon CP, et al. Properties influencing the relative binding affinity of pteroate derivatives and drug conjugates thereof to the folate receptor. Pharmaceutical research. 2009 Jun;26(6):1315-23.

[2]. Leamon CP, et al.. Folate Receptor Binding Conjugates of Antifolates. US Patent 9,192,682 B2. 2015.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Références

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EC216

Voir tous les produits spécifiques à Isoform Folate Receptor (FR)