EYE-002
EYE-002 is a RPE65 inhibitor with an IC50 of 69 nM. EYE-002 promotes recovery of scotopic ERG a-/b-wave amplitudes. EYE-002 regulates the visual cycle in mice by reducing 11-cis-retinal (11cRAL) (HY-116711) synthesis and increasing all-trans-retinyl esters (atREs). EYE-002 exerts protective effects against photic retinal damage in mice. EYE-002 can be used for the study of visual cycle-associated retinopathies, such as Stargardt disease type 1 (STGD1).
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- Formule: C16H25NO5
- Masse moléculaire:311.37
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
EYE-002 (0.1-10 μM) inhibits RPE65 activity in bovine RPE microsomes with an IC50 of 69 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
EYE-002 (10 mg/kg, i.p., 0.5-4 h post-administration, 2 h dark recovery after photobleach) restores 11cRAL and atREs levels to vehicle group levels at 4 h post-administration in BALB/cJ mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/cJ mice (6-8 weeks old, dark-adapted for 24 h)[1]
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Dosage:10 mg/kg
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Administration:i.p., 30 min pre-photobleach, 2 h dark recovery
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Result:Reduced 11-cis-retinal (11cRAL) synthesis by 78%.
Increased all-trans-retinyl esters (atREs).
Recovered 80% of scotopic ERG a- and b-wave amplitudes at 8 h dark adaptation.
Reduced retinal autofluorescent puncta, preserves outer nuclear layer (ONL) thickness, and maintained scotopic ERG a- and b-wave amplitude.
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Animal Model:BALB/cJ mice (6-8 weeks old, dark-adapted for 24 h)[1]
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Dosage:10 mg/kg
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Administration:i.p., 0.5-4 h post-administration, 2 h dark recovery after photobleach
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Result:Restored 11cRAL and atREs levels to vehicle group levels at 4 h post-administration in BALB/cJ mice.
Chemical Information
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Masse moléculaire 311.37
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Formule C16H25NO5
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SMILES
O=CO.CCC(CC)C(OC1=CC=CC(C(O)CCN)=C1)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EYE-002 Related Classifications
HY-175663 Related Classifications
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