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United States

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Cat. No.: HY-162410

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Fluplatin

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₄₈H₅₆F₂N₄O₈Pt
Masse moléculaire:1050.06

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Fluplatin Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Fluplatin is a prodrug composed of cisplatin and fluvastatin. Fluplatin has antitumor activity^[1].

In Vitro

The IC₅₀ values of Fluplatin against H1975, A549 and A549/DDP cells were 2.24, 4.57 and 4.51 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fluplatin (10.49 mg/kg, tail vein injection once every three days, a total of 5 times) shows better antitumor activity in H1975 cell subcutaneous tumor model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

H1975 tumor-bearing mouse model^[1]
Dosage:

10.49 mg/kg
Administration:

Tail vein injection, once every three days, a total of 5 times
Result:

Upregulated the expression of cleaved caspase-3.
Reduced the cholesterol level in tumor tissue.

Chemical Information

Masse moléculaire 1050.06
Formule C₄₈H₅₆F₂N₄O₈Pt
SMILES

FC1=CC=C(C=C1)C2=C(N(C3=C2C=CC=C3)C(C)C)/C=C/C(CC(CC(O[Pt]([NH3])(OC(CC(CC(/C=C/C4=C(C5=C(N4C(C)C)C=CC=C5)C6=CC=C(C=C6)F)O)O)=O)[NH3])=O)O)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bi YY, et al. Nanoparticles targeting mutant p53 overcome chemoresistance and tumor recurrence in non-small cell lung cancer. Nat Commun. 2024 Mar 29;15(1):2759. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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