Flurtamone
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Flurtamone is a herbicide that interferes with carotenoid biosynthesis by inhibiting phytoene desaturase, blocking the conversion of phytoene to ζ-carotene. Flurtamone can cause the accumulation of phytoene, leading to photooxidative destruction of chlorophyll and plant albinism. Flurtamone comprises a pair of chiral enantiomers, R-flurtamone and S-flurtamone, with R-flurtamone exhibiting significantly stronger herbicidal activity against target weeds. Flurtamone is toxic to Selenastrum capricornutum. Flurtamone can control broadleaf weeds and grass weeds as well as various weeds, and can be used in herbicide-related research.
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- Pureté : 99.95%
- CAS No.: 96525-23-4
- Formule: C18H14F3NO2
- Masse moléculaire:333.30
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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A939572 (Standard)SCD1 Inhibitor
Activité biologique
Description
In Vitro
Flurtamone inhibits phytoene desaturase activity, blocking downstream carotenoid biosynthesis and causing phytoene accumulation[1].
Flurtamone exhibits enantioselective biological effects: in germination experiments with multiple weed species, the herbicidal activity of R‑flurtamone was 6.3‑35.6 times that of S‑flurtamone, contributing 86.3‑97.3% of the total activity of the racemate; in acute toxicity experiments with Raphidocelis subcapitata, R‑flurtamone was more toxic[2].
Fluridone can induce the formation of distinct tissue zones in maize leaves. The green / pale green tissues undergo oxidative stress-induced necrosis; the albino tissues show mild oxidative damage, but the antioxidant enzymes SOD, POD, CAT, and GR are activated. The death of albino leaves is caused by carbohydrate starvation rather than membrane lipid peroxidation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 96525-23-4
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Appearance Solid
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Masse moléculaire 333.30
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Formule C18H14F3NO2
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Color White to off-white
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SMILES
O=C1C(OC(NC)=C1C2=CC=CC(C(F)(F)F)=C2)C3=CC=CC=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (300.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (286 KB)
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SDS (624 KB)
- English - EN (624 KB)
- Français - FR (624 KB)
- Deutsch - DE (624 KB)
- Norwegian - NO (624 KB)
- Español - ES (624 KB)
- Swedish - SV (624 KB)
- Italian - IT (624 KB)
- Korean - KR (624 KB)
- Portuguese - PT (624 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0003 mL | 15.0015 mL | 30.0030 mL | 75.0075 mL |
| 5 mM | 0.6001 mL | 3.0003 mL | 6.0006 mL | 15.0015 mL | |
| 10 mM | 0.3000 mL | 1.5002 mL | 3.0003 mL | 7.5008 mL | |
| 15 mM | 0.2000 mL | 1.0001 mL | 2.0002 mL | 5.0005 mL | |
| 20 mM | 0.1500 mL | 0.7501 mL | 1.5002 mL | 3.7504 mL | |
| 25 mM | 0.1200 mL | 0.6001 mL | 1.2001 mL | 3.0003 mL | |
| 30 mM | 0.1000 mL | 0.5001 mL | 1.0001 mL | 2.5003 mL | |
| 40 mM | 0.0750 mL | 0.3750 mL | 0.7501 mL | 1.8752 mL | |
| 50 mM | 0.0600 mL | 0.3000 mL | 0.6001 mL | 1.5002 mL | |
| 60 mM | 0.0500 mL | 0.2500 mL | 0.5001 mL | 1.2501 mL | |
| 80 mM | 0.0375 mL | 0.1875 mL | 0.3750 mL | 0.9376 mL | |
| 100 mM | 0.0300 mL | 0.1500 mL | 0.3000 mL | 0.7501 mL |
Flurtamone Related Classifications
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