Fomesafen-d3
Fomesafen-d3 is the deuterium-labeled Fomesafen (HY-B2010). Fomesafen is an orally active herbicide. Fomesafen inhibits protoporphyrinogen oxidase (PPO). Fomesafen induces Apoptosis and increases ROS. Fomesafen exhibits developmental toxicity, immunotoxicity, and neurotoxicity. It induces precancerous lesions in the liver and hepaturoporphyria in mice. Fomesafen is used to control broadleaf weeds in soybean fields, rubber plantations, and orchards.
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- Formule: C15H7D3ClF3N2O6S
- Masse moléculaire:441.78
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 72178-02-0
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Masse moléculaire 441.78
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Formule C15H7D3ClF3N2O6S
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SMILES
O=C(NS(=O)(C([2H])([2H])[2H])=O)C1=CC(OC2=CC=C(C(F)(F)F)C=C2Cl)=CC=C1[N+]([O-])=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Li-Xia Zhao, et al. Novel Thiazole Phenoxypyridine Derivatives Protect Maize From Residual Pesticide Injury Caused by PPO-Inhibitor Fomesafen. Biomolecules. 2019 Sep 20;9(10):514. [Content Brief]
[2]. MACAR O, et al. FOMESAFEN-INDUCED MERISTEMATIC CELL DAMAGES IN ALLIUM CEPA L.(ONION)[J].
[3]. Xu Z, et al. Effect of fomesafen on the embryonic development of zebrafish. Chemosphere. 2020 Nov;259:127380. [Content Brief]
[4]. Krijt J, et al. Experimental hepatic uroporphyria induced by the diphenyl-ether herbicide fomesafen in male DBA/2 mice. Toxicol Appl Pharmacol. 2003 May 15;189(1):28-38. [Content Brief]
[5]. Krijt J, et al. Liver preneoplastic changes in mice treated with the herbicide fomesafen. Hum Exp Toxicol. 1999 May;18(5):338-44. [Content Brief]
[6]. Zhang Q, et al. Oxidative stress and lipid peroxidation in the earthworm Eisenia fetida induced by low doses of fomesafen. Environ Sci Pollut Res Int. 2013 Jan;20(1):201-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fomesafen-d3 Related Classifications
HY-B2010S Related Classifications
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