PTGR2 - prostaglandin reductase 2 Gene

Also Known as PGR2; ZADH1; HEL-S-298

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 145482

About PTGR2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,851,831-73,885,726 (from NCBI)

This gene has 7 transcripts (splice variants), 216 orthologues and 17 paralogues. Ubiquitous expression in heart (RPKM 10.6), thyroid (RPKM 9.3) and 24 other tissues.

Summary

This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the Peroxisome Proliferator-activated Receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

PTGR2 Products (13)

mRNA Protein Name
NM_001146154.2 NP_001139626.1 prostaglandin reductase 2 isoform 1
NM_001146155.3 NP_001139627.1 prostaglandin reductase 2 isoform 1
NM_001371325.1 NP_001358254.1 prostaglandin reductase 2 isoform 1
NM_001371326.1 NP_001358255.1 prostaglandin reductase 2 isoform 2
NM_001371327.1 NP_001358256.1 prostaglandin reductase 2 isoform 3
NM_001371328.1 NP_001358257.1 prostaglandin reductase 2 isoform 3
NM_001371329.1 NP_001358258.1 prostaglandin reductase 2 isoform 3
NM_001371330.1 NP_001358259.1 prostaglandin reductase 2 isoform 4
NM_001371331.1 NP_001358260.1 prostaglandin reductase 2 isoform 4
NM_001371332.1 NP_001358261.1 prostaglandin reductase 2 isoform 4
NM_001371334.1 NP_001358263.1 prostaglandin reductase 2 isoform 5
NM_001371335.1 NP_001358264.1 prostaglandin reductase 2 isoform 6
NM_152444.4 NP_689657.1 prostaglandin reductase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
19000823 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
NOT enables zinc ion binding IDA
IDA: Inferred from direct assay
19000823 GOA
Biological Process GO Annotation Evidence Références Source
involved in prostaglandin metabolic process IDA
IDA: Inferred from direct assay
19000823 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGR2 Protein Structure

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (168 - 265)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

prostaglandin reductase 2

  • 15-oxoprostaglandin 13-reductase

PTGR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
PTGR2 Q8N8N7 BEND5 Homo sapiens Q7L4P6
Y2H Array
32296183
Intra
PTGR2 Q8N8N7 BEND5 Homo sapiens Q7L4P6
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Primary Hypertrophic Osteoarthropathy

  • Pachydermoperiostosis Syndrome

  • Osteoarthropathy, Primary Hypertrophic

  • Pachydermoperiostosis Of Nail

  • Idiopathic Hypertrophic Osteoarthropathy

  • Pho
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-122716 PTGR2-IN-1 99.82% Unkown
HY-138665 HHS-0701 Inhibitor / Unkown
HY-RS11391 PTGR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174144 RJG-2036 Inhibitor / Unkown
HY-RS17666 Ptgr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24127 Ptgr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTGR2 MGD MGI:1916372
Felis catus PTGR2 VGNC VGNC:104610
Macaca mulatta PTGR2 VGNC VGNC:99229
Rattus norvegicus PTGR2 RGD RGD:1310518