Cyp1a1 - cytochrome P450, family 1, subfamily a, polypeptide 1 Gene

Also Known as AHH; AHRR; CP11; CYP1; Cyp45c; P1-450; P450-C; P450DX; Cypc45c; P-450MC

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24296

Summary

Enables several functions, including flavonoid 3'-monooxygenase activity; heat shock protein binding activity; and oxidoreductase activity, acting on diphenols and related substances as donors. Contributes to oxidoreductase activity. Involved in several processes, including 9-cis-retinoic acid biosynthetic process; hepatocyte differentiation; and xenobiotic metabolic process. Located in mitochondrial inner membrane. Biomarker of end stage renal disease; heart disease; pulmonary hypertension; and renal cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); diabetes mellitus (multiple); gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); and lung disease (multiple). Orthologous to human CYP1A1 (Cytochrome P450 family 1 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1a1 Products (1)

mRNA Protein Name
NM_012540.3 NP_036672.3 cytochrome P450 1A1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
19401463 RGD
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
19401463 RGD
enables catalytic activity IDA
IDA: Inferred from direct assay
10381141 RGD
enables demethylase activity IDA
IDA: Inferred from direct assay
10915793 RGD
enables enzyme binding IDA
IDA: Inferred from direct assay
10891369 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
10891369 RGD
enables flavonoid 3'-monooxygenase activity IDA
IDA: Inferred from direct assay
18057719 RGD
enables monooxygenase activity IDA
IDA: Inferred from direct assay
8765131 RGD
contributes to oxidoreductase activity IDA
IDA: Inferred from direct assay
10528997 RGD
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
11339718 RGD
enables oxidoreductase activity, acting on diphenols and related substances as donors IDA
IDA: Inferred from direct assay
12054491 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9454608 RGD
enables steroid hydroxylase activity IDA
IDA: Inferred from direct assay
11370669 RGD
Biological Process GO Annotation Evidence Références Source
involved in 9-cis-retinoic acid biosynthetic process IDA
IDA: Inferred from direct assay
8765131 RGD
involved in camera-type eye development IEP
IEP: Inferred from expression pattern
15967433 RGD
involved in cellular response to copper ion IEP
IEP: Inferred from expression pattern
24599699 RGD
involved in coumarin metabolic process IDA
IDA: Inferred from direct assay
11780761 RGD
involved in dibenzo-p-dioxin catabolic process IDA
IDA: Inferred from direct assay
15812643 RGD
involved in dibenzo-p-dioxin catabolic process IMP
IMP: Inferred from mutant phenotype
12914780 RGD
involved in dibenzo-p-dioxin metabolic process IDA
IDA: Inferred from direct assay
12464257 RGD
involved in digestive tract development IEP
IEP: Inferred from expression pattern
12162855 RGD
involved in flavonoid metabolic process IDA
IDA: Inferred from direct assay
18057719 RGD
involved in hepatocyte differentiation IEP
IEP: Inferred from expression pattern
17574236 RGD
involved in insecticide metabolic process IDA
IDA: Inferred from direct assay
16169030 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
12162855 RGD
involved in maternal process involved in parturition IEP
IEP: Inferred from expression pattern
16226747 RGD
involved in nitric oxide metabolic process IEP
IEP: Inferred from expression pattern
31489946 RGD
involved in porphyrin-containing compound metabolic process IDA
IDA: Inferred from direct assay
12907239 RGD
involved in positive regulation of G1/S transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
14742689 RGD
involved in response to 2,3,7,8-tetrachlorodibenzodioxine IEP
IEP: Inferred from expression pattern
19373505 RGD
involved in response to 3-methylcholanthrene IEP
IEP: Inferred from expression pattern
10772642 RGD
involved in response to Aroclor 1254 IEP
IEP: Inferred from expression pattern
19373505 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
10329507 RGD
involved in response to diphenyl ether IEP
IEP: Inferred from expression pattern
18978342 RGD
involved in response to food IEP
IEP: Inferred from expression pattern
15740081 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
25011215 RGD
involved in response to herbicide IEP
IEP: Inferred from expression pattern
12907239 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
16497785 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
11589108 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
14726153 RGD
involved in response to iron(III) ion IEP
IEP: Inferred from expression pattern
15211619 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18308837 RGD
involved in response to nematode IEP
IEP: Inferred from expression pattern
12621079 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
10381141 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18774282 RGD
involved in tissue remodeling IEP
IEP: Inferred from expression pattern
23887904 RGD
Cellular Component GO Annotation Evidence Références Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
19401463 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 1A1

  • CYPIA1

  • P450MT2

  • P450form6

  • aryl hydrocarbon hydroxylase

  • cytochrome P1-450

  • cytochrome P450 form 6

  • cytochrome P450 subfamily I (aromatic compound-inducible) member A1 (C6 form c) (C6 form c)

  • cytochrome P450, 1a1

  • cytochrome P450, subfamily I (aromatic

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-B0822 Fipronil 99.49% Unkown
HY-B1234 Octinoxate 99.84% Unkown
HY-W017113 2-Mercaptobenzothiazole 99.85% Yes
HY-B0822R Fipronil (Standard) 99.49% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit Effect
Pureté Phase
HY-109173 Filapixant 99.10% Phase 2
HY-16031A AFP464 / Phase 2
HY-135829 BAY 2416964 Antagonist 99.59% Phase 1

Pre-clinical Phase

Bioactive Molecules (99)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-N0382 Galangin 99.99% Unkown
HY-19340 TMS Inhibitor 99.40% Unkown
HY-N2194 Bergamottin Inhibitor 99.94% Unkown
HY-N0563 Alizarin 99.48% Unkown
HY-D0145 7-Ethoxyresorufin Inhibitor 99.61% Unkown
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-134217 KYN-101 Inhibitor 98.03% Unkown
HY-Y0110 2-Naphthol 99.91% Unkown
HY-112628 CAY10464 Antagonist 99.77% Unkown
HY-W007700 8-Bromooctanoic acid 99.89% Unkown
HY-16265 JI-101 Inhibitor 98.99% Unkown
HY-N2374 Eupatorin Inhibitor 99.53% Unkown
HY-N4205 Tetrahydropiperine Inhibitor 99.41% Unkown
HY-D0932 Sudan IV 98.0% Unkown
HY-G0006 Omeprazole sulfide 99.88% Unkown
HY-N2625A Harmalol hydrochloride 99.91% Unkown
HY-117102 ANI-7 Activator 99.01% Unkown
HY-G0007 Omeprazole sulfone Control 99.23% Unkown
HY-101285 DMU2139 Inhibitor 98.0% Unkown
HY-17663 KMR-206 98.86% Unkown
HY-22024 5-Hydroxyflavone Substrate 99.83% Unkown
HY-N1082 Visnagin 99.34% Unkown
HY-124421 5F-203 Inducer 98.04% Unkown
HY-152118 CYP1B1-IN-4 Inhibitor 99.09% Unkown
HY-B0973 Dibenzothiophene Inhibitor 99.92% Unkown
HY-147128 PY109 Agonist 99.15% Unkown
HY-120377 CYP1A1 inhibitor 8a Inhibitor 98.00% Unkown
HY-124404 12(R)-HETE 99.90% Unkown
HY-N5132 (-)-Fenchone 98.0% Unkown
HY-159006 CYP1B1 ligand 3 Inhibitor 99.83% Unkown
HY-101284 DMU2105 Inhibitor 99.31% Unkown
HY-103223 Phortress Inducer 98.19% Unkown
HY-146393 PROTAC CYP1B1 degrader-1 Inhibitor 98.26% Unkown
HY-157942 CYP1B1-IN-7 Inhibitor 99.88% Unkown
HY-N8382 Chalepensin Inhibitor 98.98% Unkown
HY-RS03443 CYP1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W008003 2-Hydroxybenzimidazole Control 99.98% Unkown
HY-W713284 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate 99.87% Unkown
HY-D0145S 7-Ethoxyresorufin-d5 Inhibitor 98.89% Unkown
HY-Y0110S1 2-Naphthol-d7 99.37% Unkown
HY-B0822S1 Fipronil-13C6 98% Unkown
HY-113040A (17R,18S)-Epoxyeicosatetraenoic acid Inhibitor 93.0% Unkown
HY-118474 GW 610 Activator 99.78% Unkown
HY-N6264 26-Deoxyactein Inhibitor 99.76% Unkown
HY-W067374 Aripiprazole impurity 38 97.79% Unkown
HY-118216 Bitertanol 98.70% Unkown
HY-128920 Phortress free base Inhibitor / Unkown
HY-14225 BMS-764459 / Unkown
HY-148592 Antitumor agent-87 Inhibitor / Unkown
HY-148595 CYP1A1-IN-2 Inhibitor / Unkown
HY-150557 CYP1B1-IN-1 Inhibitor / Unkown
HY-150558 CYP1B1-IN-2 Inhibitor / Unkown
HY-152079 CYP1B1-IN-3 Inhibitor / Unkown
HY-152196 CYP1B1-IN-5 Inhibitor 98.03% Unkown
HY-158429 PROTAC CYP1B1 degrader-2 / Unkown
HY-158430 CYP1B1 ligand 2 / Unkown
HY-161403 CYP1B1-IN-8 Inhibitor / Unkown
HY-162051 CYP1B1-IN-6 Inhibitor / Unkown
HY-16265A JI-101 hydrochloride Inhibitor / Unkown
HY-174425 CYP1B1-IN-9 Inhibitor / Unkown
HY-175554 CYP1B1-IN-10 Inhibitor / Unkown
HY-175760 CYP1B1-IN-11 Inhibitor / Unkown
HY-175836 CYP1B1-IN-12 / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-181472 10(11)-Cl-BBQ / Unkown
HY-181550A CYP1B1-IN-14 TFA Inhibitor / Unkown
HY-181629 ZSTK3744 / Unkown
HY-181629A ZSTK3744 hydrochloride / Unkown
HY-183304 Anticancer agent 318 Substrate / Unkown
HY-187120 PAIB-SOs-12 Inhibitor / Unkown
HY-187206 CYP1B1-IN-15 Inhibitor / Unkown
HY-B0973S Dibenzothiophene-d8 Inhibitor / Unkown
HY-E72103 Human CYP1A1, Reductase+b5 / Unkown
HY-G0007S Omeprazole sulfone-d3 Control / Unkown
HY-G0007S1 Omeprazole sulfone-13C,d3 Control / Unkown
HY-N0382R Galangin (Standard) / Unkown
HY-N0382S Galangin-13C3 / Unkown
HY-N10344 Glucoarabin Activator / Unkown
HY-N2689 (R)-6',7'-Dihydroxybergamottin Inhibitor / Unkown
HY-RS03441 CYP1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W762015 1,2,3,6,7,8-Hexachlorodibenzofuran Inducer / Unkown
HY-Y0110S 2-Naphthol-d8 / Unkown
HY-101284A (E/Z)-DMU2105 Inhibitor / Unkown
HY-119416 Sequoiaflavone Inhibitor / Unkown
HY-126308 (E/Z)-DMU2139 Inhibitor / Unkown
HY-129247 Versicolorin A / Unkown
HY-158431 (S,R,S)-AHPC-Me-8-bromooctanoic acid / Unkown
HY-167632 meso-Zeaxanthin 93.09% Unkown
HY-174333 CYP1A1-IN-1 Inhibitor / Unkown
HY-B1234S Octinoxate-13C,d3 / Unkown
HY-D0932S Sudan IV-d6 / Unkown
HY-N0922 Methysticin Activator / Unkown
HY-RS16737 Cyp1a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16945 Cyp1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23174 Cyp1a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23388 Cyp1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown
HY-W517092 1,2,3,4,7,8,9-Heptachlorodibenzofuran / Unkown
HY-W775354 1,2,3,4,7,8-Hexachlorodibenzofuran / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp1a1 NCBI NCBI:1543