CYP1A1 - cytochrome P450 family 1 subfamily A member 1 Gene

Also Known as AHH; AHRR; CP11; CYP1; CYPIA1; P1-450; P450-C; P450DX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1543

About CYP1A1

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,719,542-74,725,528 (from NCBI)

This gene has 9 transcripts (splice variants), 252 orthologues and 2 paralogues. Biased expression in urinary bladder (RPKM 40.8), liver (RPKM 18.0) and 1 other tissue.

Summary

This gene, CYP1A1, encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung Cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

CYP1A1 Products (3)

mRNA	Protein	Name
NM_000499.5	NP_000490.1	cytochrome P450 1A1 isoform 1
NM_001319216.2	NP_001306145.1	cytochrome P450 1A1 isoform 2
NM_001319217.2	NP_001306146.1	cytochrome P450 1A1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate monooxygenase activity	IDA IDA: Inferred from direct assay	15041462	GOA
enables estrogen 16-alpha-hydroxylase activity	IDA IDA: Inferred from direct assay	11555828	GOA
enables estrogen 2-hydroxylase activity	IDA IDA: Inferred from direct assay	11555828	GOA
enables long-chain fatty acid omega-1 hydroxylase activity	IDA IDA: Inferred from direct assay	18577768	GOA
enables long-chain fatty acid omega-hydroxylase activity	IDA IDA: Inferred from direct assay	18577768	GOA
enables oxidoreductase activity	IDA IDA: Inferred from direct assay	19219744	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables vitamin D 24-hydroxylase activity	IDA IDA: Inferred from direct assay	15546903	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	23275542	GOA
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	11555828	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	15041462	GOA
involved in lipid hydroxylation	IDA IDA: Inferred from direct assay	14559847	GOA
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	18577768	GOA
involved in retinol metabolic process	IDA IDA: Inferred from direct assay	10681376	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	14559847	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	19219744	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP1A1 Protein Structure

p450

0
100
200
300
400
512 a.a.

Protein Preferred Names	Protein Names
cytochrome P450 1A1	aryl hydrocarbon hydroxylase

CYP1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CYP1A1	P04798	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	25910212
Intra	CYP1A1	P04798	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	25910212
Intra	CYP1A1	P04798	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Bait-Prey Pool	25910212
Intra	CYP1A1	P04798	CMTM5	Homo sapiens	Q96DZ9	Validated Y2H	25416956
Intra	CYP1A1	P04798	CMTM5	Homo sapiens	Q96DZ9	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Aryl Hydrocarbon Hydroxylase Inducibility	Ahh Inducibility Ahhi
Phimosis	Tight Foreskin Tight Frenulum Congenital Phimosis
Gastroschisis	Laparoschisis Congenital Fissure Of The Abdominal Cavity Abdominal Wall Defect Abdominal Hernia Hernia, Abdominal Omphalocele Abnormality Of The Abdominal Wall Congenital Omphalocele Coeloschisis Coelioschisis Celoschisis Congenital Para-Umbilical Hernia
Hepatocellular Adenoma	Adenoma Hepatocellular
Leukoplakia	Leukoplakia Of Gingiva Leukoplakia Of Oral Epithelium Leucoplakia Of Oral Mucosa Leukokeratosis Of Oral Mucosa
Breast Disease	Breast Diseases
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Paranasal Sinus Sarcoma	Sarcoma Of Accessory Sinus
Acetaminophen Metabolism
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Porphyria Cutanea Tarda	Hepatoerythropoietic Porphyria HEP Uroporphyrinogen Decarboxylase Deficiency Pct Pct, Type Ii Porphyria, Hepatocutaneous Type Urod Deficiency Porphyria, Hepatoerythropoietic Porphyria Cutanea Tarda, Susceptibility To Familial Porphyria Cutanea Tarda Porphyria Cutanea Tarda, Type Ii Pct, 'Familial' Type Porphyria, Hepatic FPCT Pct Type Ii Porphyria Cutanea Tarda Type Ii Porphyria Hepatocutaneous Type Heterozygous Uroporphyrinogen Decarboxylase Deficiency Urod - [Uroporphyrinogen Decarboxylase] Deficiency Pct - [Porphyria Cutanea Tarda]
Oral Submucous Fibrosis	Oral Submucosal Fibrosis, Including Of Tongue Osmf Oral Cavity Submucous Fibrosis Oral Submucosal Fibrosis Submucosal Fibrosis
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Hypospadias	Hypospadias Familial Familial Hypospadias
Vaginal Adenoma
Porphyria	Hematoporphyria Porphyrias Disorder Of Porphyrin And Hem Metabolism Disorder Of Porphyrin Metabolism Porphyrinopathy Porphyrin Disorder Disorder Of Porphyrin And Heme Metabolism Disorders Of Porphyrin Metabolism
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Laryngeal Squamous Cell Carcinoma	Epidermoid Carcinoma Of The Larynx Squamous Cell Carcinoma Of Larynx Squamous Cell Carcinoma Of The Larynx Squamous Cell Carcinoma Of Head And Neck
Basal Cell Carcinoma, Multiple	Multiple Basal Cell Carcinoma
Bronchitis	Chronic Bronchitis Acute Bronchitis Bronchitis, Chronic Acute Bronchitis And Bronchiolitis Chest Cold Chest Infection Ci - Chest Infection Recurrent Wheezy Bronchitis Bronchitis Chronic Lower Respiratory Tract Infection Acute Lower Respiratory Tract Infection Chronic Bronchitis Nos Senile Bronchitis Bronchitis Nos In Those Under L5 Years Of Age Bronchitis Nos
Malignant Hypertension	Hypertension, Malignant Hypertension Malignant
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Vaginal Benign Neoplasm
Bronchus Cancer	Malignant Neoplasm Of Bronchus And Lung Bronchus Carcinoma Bronchogenic Carcinoma Malignant Neoplasm Of Bronchus Or Lung Bc - Bronchogenic Carcinoma Carcinoma, Bronchogenic Bronchial Neoplasms
Lip And Oral Cavity Cancer	Oral Cancer Lip And Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Danubian Endemic Familial Nephropathy	Balkan Nephropathy Balkan Endemic Nephropathy Nephropathia Epidemica Defn Ben Aristolochic Acid Nephropathy Aan Endemic Nephropathy Balkan Balkan Nephritis
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Cork-Handlers' Disease	Suberosis Cork-Handlers' Disease Or Lung Cork-Handlers' Lung Corkhandler Disease Corkworker Lung Corkhandler Hypersensitivity Pneumonitis Cork-Handler Disease Cork-Handler Lung
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Asperger Syndrome	Asperger Disorder Asperger Syndrome, Susceptibility To
Liver Benign Neoplasm	Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Brain Cancer	Adult Brain Tumor Malignant Neoplasm Of Brain Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Amelogenesis Imperfecta, Type Ig	Enamel-Renal Syndrome Ers Amelogenesis Imperfecta Type 1g AI1G Enamel-Renal-Gingival Syndrome Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome Aigfs Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis Amelogenesis Imperfecta Type Ig Amelogenesis Imperfecta-Nephrocalcinosis Syndrome Amelogenesis Imperfecta 1g Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis Amelogenesis Imperfecta Nephrocalcinosis
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (4)

Cat. No.	상품명	Purity	Rare Diseases
HY-B0822	Fipronil	99.49%	Unkown
HY-B1234	Octinoxate	99.84%	Unkown
HY-W017113	2-Mercaptobenzothiazole	99.85%	Yes
HY-B0822R	Fipronil (Standard)	99.49%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Phase
HY-109173	Filapixant		99.10%	Phase 2
HY-16031A	AFP464		/	Phase 2
HY-135829	BAY 2416964	Antagonist	99.59%	Phase 1

Pre-clinical Phase

Bioactive Molecules (95)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-N0382	Galangin		99.99%	Unkown
HY-19340	TMS	Inhibitor	99.40%	Unkown
HY-N2194	Bergamottin	Inhibitor	99.94%	Unkown
HY-N0563	Alizarin		99.48%	Unkown
HY-D0145	7-Ethoxyresorufin	Inhibitor	99.61%	Unkown
HY-133677	Mono(2-ethyl-5-hydroxyhexyl) phthalate		99.03%	Unkown
HY-134217	KYN-101	Inhibitor	98.03%	Unkown
HY-Y0110	2-Naphthol		99.91%	Unkown
HY-112628	CAY10464	Antagonist	99.77%	Unkown
HY-W007700	8-Bromooctanoic acid		99.89%	Unkown
HY-N2374	Eupatorin	Inhibitor	99.53%	Unkown
HY-N4205	Tetrahydropiperine	Inhibitor	99.41%	Unkown
HY-D0932	Sudan IV		98.0%	Unkown
HY-G0006	Omeprazole sulfide		99.88%	Unkown
HY-N2625A	Harmalol hydrochloride		99.91%	Unkown
HY-117102	ANI-7	Activator	99.01%	Unkown
HY-G0007	Omeprazole sulfone	Control	99.23%	Unkown
HY-101285	DMU2139	Inhibitor	98.0%	Unkown
HY-17663	KMR-206		98.86%	Unkown
HY-22024	5-Hydroxyflavone	Substrate	99.83%	Unkown
HY-N1082	Visnagin		99.34%	Unkown
HY-124421	5F-203	Inducer	98.04%	Unkown
HY-152118	CYP1B1-IN-4	Inhibitor	99.09%	Unkown
HY-B0973	Dibenzothiophene	Inhibitor	99.92%	Unkown
HY-147128	PY109	Agonist	99.15%	Unkown
HY-120377	CYP1A1 inhibitor 8a	Inhibitor	98.00%	Unkown
HY-124404	12(R)-HETE		99.90%	Unkown
HY-N5132	(-)-Fenchone		98.0%	Unkown
HY-159006	CYP1B1 ligand 3	Inhibitor	99.83%	Unkown
HY-101284	DMU2105	Inhibitor	99.31%	Unkown
HY-103223	Phortress	Inducer	98.19%	Unkown
HY-146393	PROTAC CYP1B1 degrader-1	Inhibitor	98.09%	Unkown
HY-157942	CYP1B1-IN-7	Inhibitor	99.88%	Unkown
HY-N8382	Chalepensin	Inhibitor	98.98%	Unkown
HY-RS03443	CYP1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W008003	2-Hydroxybenzimidazole	Control	99.98%	Unkown
HY-W713284	2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate		99.87%	Unkown
HY-D0145S	7-Ethoxyresorufin-d5	Inhibitor	98.89%	Unkown
HY-Y0110S1	2-Naphthol-d7		99.37%	Unkown
HY-B0822S1	Fipronil-13C6		98%	Unkown
HY-113040A	(17R,18S)-Epoxyeicosatetraenoic acid	Inhibitor	93.0%	Unkown
HY-118474	GW 610	Activator	99.78%	Unkown
HY-N6264	26-Deoxyactein	Inhibitor	99.76%	Unkown
HY-W067374	Aripiprazole impurity 38		97.79%	Unkown
HY-118216	Bitertanol		98.70%	Unkown
HY-128920	Phortress free base	Inhibitor	/	Unkown
HY-14225	BMS-764459		/	Unkown
HY-148592	Antitumor agent-87	Inhibitor	/	Unkown
HY-148595	CYP1A1-IN-2	Inhibitor	/	Unkown
HY-150557	CYP1B1-IN-1	Inhibitor	/	Unkown
HY-150558	CYP1B1-IN-2	Inhibitor	/	Unkown
HY-152079	CYP1B1-IN-3	Inhibitor	/	Unkown
HY-152196	CYP1B1-IN-5	Inhibitor	98.03%	Unkown
HY-158429	PROTAC CYP1B1 degrader-2	Degrader	/	Unkown
HY-158430	CYP1B1 ligand 2		/	Unkown
HY-161403	CYP1B1-IN-8	Inhibitor	/	Unkown
HY-162051	CYP1B1-IN-6	Inhibitor	/	Unkown
HY-16265A	JI-101 hydrochloride	Inhibitor	/	Unkown
HY-174425	CYP1B1-IN-9	Inhibitor	/	Unkown
HY-175554	CYP1B1-IN-10	Inhibitor	/	Unkown
HY-175760	CYP1B1-IN-11	Inhibitor	/	Unkown
HY-175836	CYP1B1-IN-12		/	Unkown
HY-178053	AHR agonist 10		/	Unkown
HY-181472	10(11)-Cl-BBQ		/	Unkown
HY-181550A	CYP1B1-IN-14 TFA	Inhibitor	/	Unkown
HY-181629	ZSTK3744		/	Unkown
HY-181629A	ZSTK3744 hydrochloride		/	Unkown
HY-183304	Anticancer agent 318	Substrate	/	Unkown
HY-B0973S	Dibenzothiophene-d8	Inhibitor	/	Unkown
HY-G0007S	Omeprazole sulfone-d3	Control	/	Unkown
HY-G0007S1	Omeprazole sulfone-13C,d3	Control	/	Unkown
HY-N0382R	Galangin (Standard)		/	Unkown
HY-N0382S	Galangin-13C3		/	Unkown
HY-N10344	Glucoarabin	Activator	/	Unkown
HY-N2689	(R)-6',7'-Dihydroxybergamottin	Inhibitor	/	Unkown
HY-RS03441	CYP1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W762015	1,2,3,6,7,8-Hexachlorodibenzofuran	Inducer	/	Unkown
HY-Y0110S	2-Naphthol-d8		/	Unkown
HY-101284A	(E/Z)-DMU2105	Inhibitor	/	Unkown
HY-119416	Sequoiaflavone	Inhibitor	/	Unkown
HY-126308	(E/Z)-DMU2139	Inhibitor	/	Unkown
HY-129247	Versicolorin A		/	Unkown
HY-158431	(S,R,S)-AHPC-Me-8-bromooctanoic acid		/	Unkown
HY-167632	meso-Zeaxanthin		93.09%	Unkown
HY-174333	CYP1A1-IN-1	Inhibitor	/	Unkown
HY-B1234S	Octinoxate-13C,d3		/	Unkown
HY-D0932S	Sudan IV-d6		/	Unkown
HY-N0922	Methysticin	Activator	/	Unkown
HY-RS16737	Cyp1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16945	Cyp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23174	Cyp1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23388	Cyp1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown
HY-W517092	1,2,3,4,7,8,9-Heptachlorodibenzofuran		/	Unkown
HY-W775354	1,2,3,4,7,8-Hexachlorodibenzofuran		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CYP1A1	MGD	MGI:88588
Bos taurus	CYP1A1	VGNC	VGNC:110232
Macaca mulatta	CYP1A1	VGNC	VGNC:103596
Felis catus	CYP1A1	VGNC	VGNC:103317
Rattus norvegicus	CYP1A1	RGD	RGD:2458
Canis familiaris	CYP1A1	VGNC	VGNC:50332
Others	CYP1A1	NCBI