MSI1 - musashi RNA binding protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4440

About MSI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,339,662-120,369,164 (from NCBI)

This gene has 3 transcripts (splice variants), 286 orthologues, 36 paralogues and is associated with 1 phenotype. Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues.

Summary

This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in Other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]

MSI1 Products (15)

mRNA Protein Name
NM_001414485.1 NP_001401414.1 RNA-binding protein Musashi homolog 1 isoform b
NM_001414486.1 NP_001401415.1 RNA-binding protein Musashi homolog 1 isoform c
NM_001414487.1 NP_001401416.1 RNA-binding protein Musashi homolog 1 isoform d
NM_001414488.1 NP_001401417.1 RNA-binding protein Musashi homolog 1 isoform e
NM_001414489.1 NP_001401418.1 RNA-binding protein Musashi homolog 1 isoform f
NM_001414490.1 NP_001401419.1 RNA-binding protein Musashi homolog 1 isoform g
NM_001414491.1 NP_001401420.1 RNA-binding protein Musashi homolog 1 isoform h
NM_001414492.1 NP_001401421.1 RNA-binding protein Musashi homolog 1 isoform i
NM_001414493.1 NP_001401422.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414494.1 NP_001401423.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414495.1 NP_001401424.1 RNA-binding protein Musashi homolog 1 isoform j
NM_001414496.1 NP_001401425.1 RNA-binding protein Musashi homolog 1 isoform k
NM_001414497.1 NP_001401426.1 RNA-binding protein Musashi homolog 1 isoform l
NM_001414498.1 NP_001401427.1 RNA-binding protein Musashi homolog 1 isoform l
NM_002442.4 NP_002433.1 RNA-binding protein Musashi homolog 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
30367664 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30367664 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSI1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (23 - 90)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (111 - 177)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

RNA-binding protein Musashi homolog 1

  • musashi-1

MSI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MSI1 O43347 HNRNPH2 Homo sapiens P55795
Validated Y2H
32296183
Intra
MSI1 O43347 HNRNPF Homo sapiens P52597
Validated Y2H
32296183
Intra
MSI1 O43347 MSI1 Homo sapiens O43347
Comigration in SDS
30367664
Intra
MSI1 O43347 MSI1 Homo sapiens O43347
AFM
30367664
Cross: Cross-species interaction Intra: Intraspecies interaction

MSI1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P83070 Musashi 1/Msi1 Antibody (YA2815) WB, IHC-P, ICC/IF, IP, FC Human
HY-P85283 Musashi 1/Msi1 Antibody (YA4975) WB; IHC-P; IHC-F; IF-Tissue; IP; FC; ICC/IF Human
HY-P85563 Musashi 1/Msi1 Antibody (YA5255) WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Omsk Hemorrhagic Fever

  • Ohf

  • Hemorrhagic Fever, Omsk

  • Ohf - [Omsk Haemorrhagic Fever]

  • Spring-Fall Haemorrhagic Fever
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
High Grade Glioma

  • Malignant Glioma

  • Glial Cell Tumor

  • Glioma, Malignant

  • Malignant Neuroglial Tumor

  • Neuroglial Tumor

  • Glioma

  • Malignant Gliomas
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Gliosarcoma

  • Glioblastoma With Sarcomatous Component

  • Sarcomatous Glioblastoma
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-119734 Gossypolone 96.28% Unkown
HY-RS08714 MSI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22242 Msi1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28764 Msi1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MSI1 VGNC VGNC:68325
Bos taurus MSI1 VGNC VGNC:31697
Macaca mulatta MSI1 VGNC VGNC:74935
Rattus norvegicus MSI1 RGD RGD:628778
Mus musculus MSI1 MGD MGI:107376
Canis familiaris MSI1 VGNC VGNC:43442
Others MSI1 NCBI