VSIR - V-set immunoregulatory receptor Gene

Also Known as B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64115

About VSIR

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:71,747,556-71,773,520 (from NCBI)

This gene has 3 transcripts (splice variants), 482 orthologues and 14 paralogues. Broad expression in spleen (RPKM 39.2), bone marrow (RPKM 38.8) and 23 other tissues.

Summary

Enables endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

VSIR Products (1)

mRNA	Protein	Name
NM_022153.2	NP_071436.1	V-type immunoglobulin domain-containing suppressor of T-cell activation precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables endopeptidase activator activity	IDA IDA: Inferred from direct assay	20666777	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	20666777	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26228159	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	24691993	GOA
involved in negative regulation of CD8-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	24691993	GOA
involved in negative regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	24691993	GOA
involved in negative regulation of interleukin-17 production	IDA IDA: Inferred from direct assay	24691993	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	24691993	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	24691993	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	20666777	GOA
involved in positive regulation of collagen catabolic process	IDA IDA: Inferred from direct assay	20666777	GOA
involved in positive regulation of endopeptidase activity	IDA IDA: Inferred from direct assay	20666777	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20666777	GOA
involved in positive regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	24691993	GOA
involved in zymogen activation	IDA IDA: Inferred from direct assay	20666777	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20666777	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VSIR Protein Structure

V-set

0
100
200
311 a.a.

Protein Preferred Names	Protein Names
V-type immunoglobulin domain-containing suppressor of T-cell activation	Death Domain1alpha

VSIR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	VSIR	Q9H7M9	TMEM14C	Homo sapiens	Q9P0S9	Validated Y2H	32296183
Intra	VSIR	Q9H7M9	VSIR	Homo sapiens	Q9H7M9	Pull Down	26228159
Intra	VSIR	Q9H7M9	VSIR	Homo sapiens	Q9H7M9	Anti Tag CoIP	26228159
Intra	VSIR	Q9H7M9	VSIR	Homo sapiens	Q9H7M9	Crosslink	26228159
Intra	VSIR	Q9H7M9	SMCO4	Homo sapiens	Q9NRQ5	Validated Y2H	32296183
Intra	VSIR	Q9H7M9	TMEM100	Homo sapiens	Q9NV29	Validated Y2H	32296183
Intra	VSIR	Q9H7M9	DOLK	Homo sapiens	Q9UPQ8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VSIR Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P70983	VISTA/B7-H5 Protein, Human (HEK293, His)	AAH20568.1 (F33-A194)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P77879	VISTA/B7-H5 Protein, Human (HEK293, Fc)	Q9H7M9 (F33-A194)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78929	VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, Fc-Avi)	Q9H7M9 (F33-A194)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78936	VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9H7M9 (F33-A194)	≥ 95%, as determined by reducing SDS-PAGE.

VSIR Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81531	VISTA Antibody (YA1276)	IHC-P	Human
HY-P81531A	VISTA Antibody (YA1276)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15711	VSIR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18981	Vsir Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25470	Vsir Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P991447	Anti-VSIR/VISTA Antibody (SG7)	Inhibitor	98.07%	Unkown
HY-P991165	Trovostobart		99.17%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	VSIR	VGNC	VGNC:79834
Canis familiaris	VSIR	VGNC	VGNC:51998
Bos taurus	VSIR	VGNC	VGNC:50150
Rattus norvegicus	VSIR	RGD	RGD:1590938
Felis catus	VSIR	VGNC	VGNC:66980
Mus musculus	VSIR	MGD	MGI:1921298
Others	VSIR	NCBI