CALCA - calcitonin related polypeptide alpha Gene

Also Known as CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I; CGRP-alpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 796

About CALCA

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:14,966,668-14,972,351 (from NCBI)

This gene has 7 transcripts (splice variants), 69 orthologues and 2 paralogues. Restricted expression toward thyroid (RPKM 13.7).

Summary

This gene encodes the peptide hormones Calcitonin, Calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014]

CALCA Products (5)

mRNA	Protein	Name
NM_001033952.3	NP_001029124.1	calcitonin isoform CT preproprotein
NM_001033953.3	NP_001029125.1	calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein
NM_001378949.1	NP_001365878.1	calcitonin isoform CT preproprotein
NM_001378950.1	NP_001365879.1	calcitonin isoform alpha-CGRP preproprotein
NM_001741.3	NP_001732.1	calcitonin isoform CT preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables calcitonin receptor binding	IPI IPI: Inferred from physical interaction	8078488	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	23395606	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9620797	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	14722252	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	16014619	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in G protein-coupled receptor internalization	IDA IDA: Inferred from direct assay	10882736	GOA
involved in activation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	10822112	GOA
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	17983652	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11014233	GOA
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	18603306	GOA
involved in antifungal humoral response	IDA IDA: Inferred from direct assay	18603306	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	18603306	GOA
involved in calcitonin gene-related peptide receptor signaling pathway	IDA IDA: Inferred from direct assay	10882736	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: Inferred from direct assay	18603306	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	18603306	GOA
involved in embryo implantation	IDA IDA: Inferred from direct assay	17983652	GOA
involved in endothelial cell migration	IDA IDA: Inferred from direct assay	17267696	GOA
involved in endothelial cell proliferation	IDA IDA: Inferred from direct assay	17267696	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	18603306	GOA
involved in leukocyte cell-cell adhesion	IDA IDA: Inferred from direct assay	1326102	GOA
involved in monocyte chemotaxis	IDA IDA: Inferred from direct assay	15248232	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11014233	GOA
acts upstream of or within negative regulation of blood pressure	IDA IDA: Inferred from direct assay	10642343	GOA
involved in negative regulation of bone resorption	IDA IDA: Inferred from direct assay	10822112	GOA
involved in negative regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	16014619	GOA
involved in negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	10822112	GOA
acts upstream of or within nervous system process involved in regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	10642343	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9685362	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	17983652	GOA
involved in positive regulation of interleukin-1 alpha production	IDA IDA: Inferred from direct assay	16904178	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	16904178	GOA
involved in positive regulation of macrophage differentiation	IDA IDA: Inferred from direct assay	10822112	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	20596610	GOA
involved in receptor internalization	IDA IDA: Inferred from direct assay	10882736	GOA
involved in regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	9685362	GOA
involved in response to yeast	IDA IDA: Inferred from direct assay	18603306	GOA
involved in vasculature development	IDA IDA: Inferred from direct assay	17267696	GOA
involved in vasodilation	IDA IDA: Inferred from direct assay	3266556	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17267696	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	2408883	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCA Protein Structure

Calc_CGRP_IAPP

0
100
141 a.a.

Protein Preferred Names	Protein Names
calcitonin calcitonin gene-related peptide 1	alpha-type CGRP

Protein Preferred Names

Protein Names

calcitonin

calcitonin gene-related peptide 1

alpha-type CGRP

CALCA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	CALCA	P01258	GIP	Homo sapiens	P09681	Anti Tag CoIP	33961781
Intra	CALCA	P01258	CALCA	Homo sapiens	P01258	EM	23395606
Intra	CALCA	P01258	CRBN	Homo sapiens	Q96SW2	Anti Tag CoIP	33961781
Intra	CALCA	P01258	CALCA	Homo sapiens	P01258	X-Ray Fiber Diffrac	23395606
Intra	CALCA	P01258	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	CALCA	P01258	CALCA	Homo sapiens	P01258	IR Spectrometry	23395606
Intra	CALCA	P01258	ATP2B4	Homo sapiens	P23634	Anti Bait CoIP	17689535
Intra	CALCA	P01258	DCAF6	Homo sapiens	Q58WW2	Anti Tag CoIP	33961781
Intra	CALCA	P01258	LRP2	Homo sapiens	P98164	Anti Tag CoIP	33961781
Intra	CALCA	P01258	ATP2B2	Homo sapiens	Q01814	Anti Bait CoIP	17689535
Intra	CALCA	P01258	PHF1	Homo sapiens	O43189	Anti Tag CoIP	33961781
Intra	CALCA	P01258	NCOA1	Homo sapiens	Q15788	Anti Tag CoIP	33961781
Intra	CALCA	P06881	CALCRL	Homo sapiens	Q16602	GMS	30209400
Intra	CALCA	P06881	CALCRL	Homo sapiens	Q16602	3D-EM	30209400
Intra	CALCA	P06881	CALCRL	Homo sapiens	Q16602	3D-EM-Single	33602864
Intra	CALCA	P01258	CALCR	Oryctolagus cuniculus	P79222-1	Saturation Binding	8940110

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CALCA Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P7707	Calcitonin/CALCA Protein, Human (HEK293, His)	P01258-1 (A26-N141)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7708	Calcitonin/CALCA Protein, Human (His, solution)	P01258-1 (Y58-N141)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P71702	Calcitonin/CALCA Protein, Human (GST)	P06881 (A83-A118)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P77586	Calcitonin/CALCA Protein, Human (HEK293, Fc)	P01258-1 (A26-N141)	≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P700614	Calcitonin/CALCA Protein, Human (P. pastoris, His-SUMO)	P06881 (A83-F119)	≥ 95%, as determined by reducing SDS-PAGE.

CALCA Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81099	Calcitonin Antibody (YA3485)	IHC-P	Human
HY-P86028	Calcitonin Antibody (YA5720)	IHC-P, ICC/IF, ELISA	Human
HY-P86811	CGRP Antibody (YA6504)	IHC-F, IHC-P, WB	Human, Mouse, Rat
HY-P86812	CGRP Antibody (YA6505)	WB, ICC/IF, IHC-P, FC, IHC-F	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Reflex Sympathetic Dystrophy	Algodystrophy Reflex Sympathetic Dystrophy Syndrome Complex Regional Pain Syndrome Type 1 Complex Regional Pain Syndromes Algodystrophic Syndrome
Complex Regional Pain Syndrome	Complex Regional Pain Syndromes Reflex Sympathetic Dystrophy Crps
Spinal Stenosis	Lumbar Spinal Stenosis Cervical Spinal Stenosis Spinal Stenosis Of Lumbar Region Spinal Stenosis In Cervical Region Spinal Canal Stenosis
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Giant Cell Reparative Granuloma	Central Giant Cell Granuloma Central Giant Cell Reparative Granuloma Of Jaw Central Giant Cell Granuloma Granuloma, Giant Cell Granuloma, Giant Cell Reparative Giant Cell Lesion Of Small Bones Giant Cell Granuloma, Nos
Multiple Endocrine Neoplasia	Men Multiple Endocrine Adenomatosis Multiple Endocrine Neoplasia Syndrome Adenomatosis, Familial Endocrine Endocrine Neoplasia, Multiple Familial Endocrine Adenomatosis Mea Multiple Endocrine Neoplasms Multiple Endocrine Neoplasia Type 1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Multiple Endocrine Neoplasia, Type Iia	Multiple Endocrine Neoplasia Type 2a Sipple Syndrome Multiple Endocrine Neoplasia Type 2 MEN2A Men2 Ptc Syndrome Multiple Endocrine Neoplasia, Type 2 Multiple Endocrine Neoplasia Iia Men 2a Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia, Type 2a Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma Multiple Endocrine Neoplasia Ii Men2 Syndrome Men-2a Syndrome Multiple Neoplasia 2a Multiple Neoplasia Type 2
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Cluster Headache	Headache, Cluster
Renal Osteodystrophy	Renal Rickets Chronic Kidney Disease-Mineral And Bone Disorder
Primary Hyperparathyroidism	Familial Primary Hyperparathyroidism Hyperparathyroidism, Primary Hyperparathyroidism Primary Hypocalciuric Hypercalcemia, Familial, Type 1 Familial Benign Hypercalcemia Familial Hyperparathyroidism Parathyroid Enlargement
Papillary Carcinoma	Carcinoma, Papillary Carcinoma Papillary
Paget'S Disease Of Bone	Osteitis Deformans Paget Disease Of Bone Osseous Paget'S Disease Paget Disease Of Bone, Familial Bone Paget Disease Familial Paget'S Disease Of Bone Paget'S Bone Disease Familial Paget Disease Of Bone Paget Disease, Bone Pdb Pagets Bone Disease
Discitis
Hyperparathyroidism	Hyperparathyroidism And Other Disorders Of Parathyroid Gland Parathyroid Hyperfunction Hpth - [Hyperparathyroidism] Parathyroid Gland Hyperfunction Parathyroid Glandular Hyperfunction
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Neuroendocrine Tumor	Neuroendocrine Neoplasm Neuroendocrine Tumors Carcinoma, Neuroendocrine
Vipoma	Wdha Syndrome Pancreatic Cholera Pancreatic Vipoma Verner-Morrison Syndrome Diarrheogenic Islet Cell Tumor Vip-Secreting Tumor Malignant Vasoactive Intestinal Peptide-Secreting Tumor Vasoactive Intestinal Peptide-Secreting Tumor Vip- Secreting Tumor Vipoma, Malignant Vipoma Syndrome Watery Diarrhea Syndrome Watery Diarrhea, Hypokalemia, And Achlorhydria Syndrome Vasoactive Intestinal Peptide Tumor Vasoactive Intestinal Peptide-Producing Tumor Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome Malignant Vipoma
Follicular Adenoma	Follicular Adenoma Of The Thyroid Gland Thyroid Follicular Adenoma Adenoma Follicular Follicular Thyroid Adenoma Thyroid Gland Follicular Adenoma
Vasomotor Rhinitis	Rhinitis, Vasomotor Rhinitis Vasomotor Vmr - [Vasomotor Rhinitis]
Secondary Hyperparathyroidism	Hyperparathyroidism Secondary Hyperparathyroidism, Secondary Secondary Hyperparathyroidism Nec
Osteitis Fibrosa	Osteitis Fibrosa Cystica Hyperparathyroid Bone Disease Osteitis Fibrosa Cystica Generalisata Von Recklinghausen'S Bone Disease Osteitis Fibrosa Disseminata
Thyroid Gland Medullary Carcinoma	Medullary Thyroid Carcinoma Medullary Carcinoma Of The Thyroid Gland Ultimobranchial Thyroid Tumor Ultimobranchial Thyroid Tumour Thyroid Cancer, Medullary
Islet Cell Tumor	Pancreatic Neuroendocrine Tumor Neuroendocrine Tumor Of Pancreas Pnet Pancreatic Net Pancreatic Endocrine Tumor Well-Differentiated Nen Of Pancreas Well-Differentiated Neuroendocrine Neoplasm Of Pancreas Well-Differentiated Pancreatic Nen Well-Differentiated Pancreatic Neuroendocrine Neoplasm Endocrine Pancreas Cancer Islet Cell Neoplasm Islet Cell Tumour Malignant Pancreatic Endocrine Tumor Malignant Pancreatic Endocrine Tumour Malignant Tumor Of Endocrine Pancreas Malignant Tumour Of Endocrine Pancreas Pancreatic Endocrine Neoplasm Pancreatic Neuroendocrine Neoplasm Adenoma, Islet Cell Well Differentiated Pancreatic Endocrine Tumor Malignant Neoplasm Of Endocrine Pancreas Pancreatic Endocrine Carcinoma
Bone Giant Cell Tumor	Giant Cell Tumor Of Bone Osteoclastoma Gct Of Bone Bone Giant Cell Tumour Giant Cell Myeloma Giant Cell Neoplasm Of Bone Giant Cell Tumour Of Bone
Osteomalacia	Adult Rickets
Thyroiditis	Inflammation Of Thyroid Thyroiditis Nos
Goiter	Goitre
Bone Disease	Bone Diseases Skeletal Disease Skeletal Disorder Disorder Of Skeletal System
Root Resorption
Algoneurodystrophy	Reflex Sympathetic Dystrophy Algoneurodystrophy, Site Unspecified
Multiple Endocrine Neoplasia, Type Iib	Multiple Endocrine Neoplasia Type 2b MEN2B Wagenmann-Froboese Syndrome Multiple Endocrine Neoplasia Iib Mucosal Neuroma Syndrome Multiple Endocrine Neoplasia, Type 3 Multiple Endocrine Neoplasia, Type 2b Men Iib Neuromata, Mucosal, With Endocrine Tumors Multiple Endocrine Neoplasia, Type Iii, Formerly Men3, Formerly Men Type Iib Men 2b Multiple Endocrine Neoplasia Type 3 Multiple Neoplasia 2b Neoplasia, Endocrine, Multiple, Type Iib
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Neuroendocrine Carcinoma	Neuroendocrine Cancer Carcinoma Neuroendocrine Carcinoma, Neuroendocrine
Parathyroid Carcinoma	Parathyroid Cancer Parathyroid Neoplasms Malignant Tumor Of Parathyroid Gland PRTC Carcinoma Of Parathyroid Gland Malignant Neoplasm Of Parathyroid Gland Parathyroid Gland Adenocarcinoma Parathyroid Gland Cancer Parathyroid Neoplasm Parathyroid Gland Carcinoma Malignant Neoplasm Of The Parathyroid Neoplasm Of Parathyroid Gland Parathyroid Gland Neoplasm Cancer Of The Parathyroid Cancer Of The Parathyroid Gland Malignant Neoplasm Of Parathyroid Malignant Parathyroid Gland Neoplasm Malignant Parathyroid Gland Tumor Malignant Parathyroid Neoplasm Malignant Parathyroid Tumor Malignant Tumor Of Parathyroid Parathyroid Adenocarcinoma Neoplasm Of The Parathyroid Gland Carcinoma, Parathyroid
Paraganglioma	Chemodectoma Glomus Body Tumor Paragangliomas Carotid Body Paraganglioma Extra-Adrenal Paraganglioma
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Mucoepidermoid Carcinoma	Mec Salivary Gland Mucoepidermoid Carcinoma C3772 Carcinoma Mucoepidermoid Carcinoma, Mucoepidermoid
Fibrous Dysplasia	Fibrous Dysplasia Of Bone
Erysipelas
Nodular Goiter	Goiter, Nodular Nodular Goitre Goiter Nodular Non-Toxic Nodular Goiter
Hypercalcemia, Infantile, 1	HCINF1 Infantile Hypercalcemia Hypercalcemia Hypercalcemia, Idiopathic, Of Infancy Hypercalcemia Infantile Idiopathic Hypercalcemia Of Infancy Hypercalcemia, Infantile Hypercalcemia, Infantile, Type 1
Osteoporosis, Juvenile	Idiopathic Juvenile Osteoporosis Idiopathic Osteoporosis Juvenile Osteoporosis Ijo
Parathyroid Adenoma	Adenoma Of Parathyroid Adenoma Of The Parathyroid Gland Parathyroid Gland Adenoma
Benign Giant Cell Tumor	Giant Cell Tumors
Multiple Mucosal Neuroma
Gorham'S Disease	Gorham-Stout Syndrome Osteolysis, Essential Disappearing Bone Disease Essential Osteolysis Gorham Disease Massive Osteolysis Phantom Bone Disease Cystic Angiomatosis Of Bone Diffuse Gorham-Stout Disease Osteolysis Massive Vanishing Bone Disease Massive Osteolyses
Multinodular Goiter
Ileus	Ileus Of Intestine
Burning Mouth Syndrome	Orodynia Stomatodynia Stomatopyrosis Bms Burning Mouth Disorder Oral Dysesthesia Sore Mouth Syndrome Bms - [Burning Mouth Syndrome]
Laryngeal Neuroendocrine Tumor	Laryngeal Neuroendocrine Tumour Neuroendocrine Tumor Of Larynx Neuroendocrine Tumour Of Larynx Neuroendocrine Neoplasm Of Larynx
Aneurysmal Bone Cysts	Aneurysmal Bone Cyst Bone Cysts Aneurysmal Bone Cysts, Aneurysmal
Myofascial Pain Syndrome	Myofascial Pain Syndromes Myofascial Pain Dysfunction Syndrome Fibromyalgia
Papillary Thyroid Microcarcinoma
Hypocalcemia, Autosomal Dominant 1	Autosomal Dominant Hypocalcemia Autosomal Dominant Hypocalcemia 1 HYPOC1 Hypocalcemia, Autosomal Dominant Hypercalciuric Hypocalcemia Hypocalcemia, Autosomal Dominant, With Bartter Syndrome Familial Hypocalcemia Hypocalcemia, Familial Hypoc Adh Autosomal Dominant Hypoparathyroidism Familial Hypercalciuric Hypocalcemia Ad Hypocalcemia Autosomal Dominant Hypocalcemia With Bartter Syndrome Hypoparathyroidism - Autosomal Dominant Hypocalcemia
Hemiplegia	Infantile Hemiplegia Postnatal Infantile Hemiplegia Hemiplegia, Infantile
Causalgia	Complex Regional Pain Syndrome, Type Ii Complex Regional Pain Syndrome Type 2
Hypoparathyroidism	Hypoparathyroidism, Idiopathic Parathyroid, Underactivity Of Syndrome With Hypoparathyroidism Deficiency Of Parathyroid Hormone Parathyroid Gland Insufficiency Parathyroid Insufficiency Hypoparathyroidism Due To Impaired Pth - [Parathyroid Hormone] Secretion
Somatostatinoma	Somatostatin Cell Neoplasm Somatostatin Cell Tumour Ampullary Somatostatinoma Carcinoid Somatostatinoma Malignant Islet Cell Tumor Somatomedin-Secreting Carcinoid Somatostatin-Secreting Pancreatic Neoplasm Pancreatic Somatostatinoma Pancreatic Endocrine Carcinoma
Thyroid Lymphoma
Gastric Ulcer	Stomach Ulcer Acute Gastric Ulcer With Haemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction Acute Gastric Ulcer With Hemorrhage, With Obstruction Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction Acute Gastric Ulcer With Perforation Acute Gastric Ulcer With Perforation And Obstruction Acute Gastric Ulcer With Perforation, With Obstruction Acute Gastric Ulcer Without Hemorrhage And Without Perforation Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction Bleeding Acute Gastric Ulcer Chronic Gastric Ulcer Without Hemorrhage And Without Perforation Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction Gastric Ulcers Cushings Ulcer Cushing'S Ulcer Of Stomach Peptic Ulcer Of Stomach Mucosal Defect Of The Stomach
Thyroid Gland Disease	Abnormality Of The Thyroid Gland Thyroid Diseases
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Spindle Epithelial Tumor With Thymus-Like Differentiation Tumor	Settle Tumor Settle Tumour Spindle Epithelial Tumour With Thymus-Like Differentiation Tumour
Pyelonephritis
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Mineral Metabolism Disease	Mineral Metabolism Disorder Disorder Of Mineral Metabolism
Cholecystitis	Acute Cholecystitis Chronic Cholecystitis Acalculous Cholecystitis Acute And Chronic Cholecystitis Acute On Chronic Cholecystitis Gallstone Cholecystitis Cholecystitis, Acute Calculus Of Gallbladder With Cholecystitis Gallbladder Inflammation Acute Cholecystitis Infection Acute Acalculous Cholecystitis Chronic Acalculous Cholecystitis Nonfunctioning Gallbladder
Calcinosis	Pathologic Calcification Pathologically Calcified Structure
Hyperthyroidism	Overactive Thyroid
Fetal Adenoma	Microfollicular Adenoma
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Carcinoid Syndrome	Carcinoid Tumor Malignant Carcinoid Syndrome Carcinoid Tumor Syndrome Carcinoid Tumors Carcinoid Tumor No Icd-O Subtype Argentaffinoma Syndrome
Constipation
Substernal Goiter	Retrosternal Thyroid Goiter Retrosternal Thyroid Goitre Substernal Goitre Goiter, Substernal
Neuroma
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm
Mammary Paget'S Disease	Paget'S Disease Mammary Paget Disease Paget'S Disease Of The Breast Paget Disease Of The Breast Paget'S Disease Of The Nipple Paget'S Disease, Mammary Paget Cell Neoplasm Paget Disease Of The Nipple Pagets Disease Mammary Osteitis Deformans
Parathyroid Gland Disease	Parathyroid Diseases Disease Of Parathyroid Glands Parathyroid Disease
Tetanic Cataract	Hypocalcaemic Cataract
Thyroid Sarcoma	Sarcoma Of The Thyroid Gland Thyroid Gland Sarcoma
Duodenal Ulcer	Stress Ulcer Curling Ulcer Stress Ulcer Of Stomach Curling'S Ulcers Duodenal Ulcer Disease Duodenal Ulcers Duodenal Peptic Ulcer
Trigeminal Nerve Disease	Trigeminal Nerve Diseases Disorders Of 5th Cranial Nerve Disorders Of The Fifth Cranial Nerve
Paget Disease Of Bone 5, Juvenile-Onset	Juvenile Paget Disease Hyperostosis Corticalis Deformans Juvenilis Jpd Hereditary Hyperphosphatasia Hyperphosphatasemia With Bone Disease Hyperphosphatasia, Familial Idiopathic PDB5 Hyperphosphatasemia, Chronic Congenital Idiopathic Osteoectasia, Familial Jpg Familial Osteoectasia Paget Disease, Juvenile Hyperostosid Corticalis Deformans Juvenilis Juvenile Pagets Disease Paget Disease Juvenile Type Chronic Congenital Idiopathic Hyperphosphatasemia Familial Idiopathic Hyperphosphatasemia Idiopathic Hyperphosphatasia Juvenile Paget'S Disease Osteochalasia Desmalis Familiaris Osteoectasia With Hyperphosphatasia Chronic Congenital Idiopathic Hyperphosphatasia Paget Disease Of Bone, Type 5, Juvenile-Onset Juvenile Osteitis Deformans
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Thyroid Cancer, Nonmedullary, 2	Thyroid Carcinoma, Follicular Follicular Thyroid Carcinoma NMTC2 Thyroid Cancer, Follicular Thyroid Carcinoma, Follicular, Somatic Ftc Thyroid Cancer, Non-Medullary, 2 Thyroid Follicular Carcinoma Follicular Thyroid Cancer Cancer, Thyroid, Nonmedullary, Type 2 Thyroid Gland Adenocarcinoma Follicular Carcinoma Of Unspecified Site Moderately Differentiated Follicular Carcinoma Of Thyroid Gland Pure Follicle Carcinoma Of Thyroid Gland Pure Follicle Follicular Carcinoma Of Unspecified Site Pure Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Thyroid Gland Trabecular Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Unspecified Site Well Differentiated Follicular Carcinoma Of Thyroid Gland
Osteomyelitis
Cherubism	CRBM Familial Benign Giant-Cell Tumor Of The Jaw Familial Fibrous Dysplasia Of Jaw Familial Multilocular Cystic Disease Of The Jaws
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Hashimoto Thyroiditis	Autoimmune Thyroiditis Hashimoto Struma Hashimoto'S Thyroiditis Chronic Lymphocytic Thyroiditis Lymphocytic Thyroiditis Hashimoto Disease Ht Hashimoto'S Disease Hashimoto'S Syndrome Hypothyroidism, Autoimmune Autoimmune Chronic Lymphocytic Thyroiditis Chronic Lymphocytic Thyroiditides Hashimoto Syndrome Hashimotos Thyroiditis Hashimoto Thyroiditis, Susceptibility To Thyroiditis, Autoimmune Lymphomatous Thyroiditis Lymphoid Thyroiditis Chronic Lymphadenoid Thyroiditis Autoimmune Lymphocytic Chronic Thyroiditis Goitre Lymphomatosa Hashitoxicosis Hashimoto Hypothyroidism Lymphadenoid Goitre Struma Lymphomatosa Hyperthyroidism With Hashimoto Disease Hashimoto Thyrotoxicosis Thyrotoxicosis Due To Hashimoto Thyroiditis Struma Lymphomatosis Lymphadenoid Struma
Rickets	Vitamin D Deficiency Vitamin D Active Rickets Hypovitaminosis D Nutritional Rickets Vitamin D Deficiency Disease Vitamin-D Deficiency Rickets Vitamin D-Dependent Rickets Avitaminosis D Infantile Osteomalacia Juvenile Osteomalacia
Epithelial Malignant Thymoma	Squamoid Thymoma Thymoma, Epithelial Well Differentiated Thymic Carcinoma Thymoma, Type B3
Glucocorticoid-Induced Osteoporosis	Steroid-Induced Osteoporosis
Bone Resorption Disease	Bone Resorption
Diabetes Insipidus
Impetigo
Bone Remodeling Disease
Acute Thyroiditis	Infectious Thyroiditis
Atypical Follicular Adenoma
Osteopetrosis	Marble Bone Disease Albers-Schonberg Disease Osteopetroses Marble Bones Osteopetrosis And Related Disorders Congenital Osteopetrosis Marble Bone Albers-Schoenberg Disease Albers-Schonberg Osteopetrosis Osteosclerosis Fragilis Ivory Bones
Pseudohypoparathyroidism	Familial Pseudohypoparathyroidism Parathyroid Hormone Resistant Hypoparathyroidism Php - [Pseudohypoparathyroidism] Constitutional Chronic Hypocalcaemia
Gastroenteritis	Cholera Morbus Infectious Colitis, Enteritis And Gastroenteritis Enteritis Due To Astrovirus Rotaviral Gastroenteritis Viral Gastroenteritis Due To Rotavirus
Carbamazepine Allergy	Carbamazepen Allergy Tegretol Allergy
Plantar Fasciitis	Fasciitis, Plantar
Epicondylitis	Tennis Elbow Lateral Epicondylitis Golfer'S Elbow Medial Epicondylitis Andrel Epicondylitis Archer'S Elbow Hockey Elbow Shooter'S Elbow
Thyroid Angiosarcoma	Hemangiosarcoma Of The Thyroid
Endemic Goiter	Iodine-Deficiency-Related Endemic Goitre Simple Goitre Goiter, Endemic Euthyroid Goiter
Suppurative Thyroiditis	Thyroiditis, Suppurative Acute Suppurative Thyroiditis Infectious Thyroiditis
Malignant Ovarian Brenner Tumor	Malignant Brenner Tumor
Bone Benign Neoplasm
Breast Adenocarcinoma	Mammary Adenocarcinoma Adenocarcinoma Of Breast
Taylor'S Syndrome	Pelvic Congestion Syndrome Congestion-Fibrosis Syndrome Taylor Syndrome
Conn'S Syndrome	Cushing Syndrome Hyperaldosteronism Primary Hyperaldosteronism Hypercortisolism Primary Aldosteronism Cushing'S Syndrome Adrenal Gland Hyperfunction Conn Syndrome Hyperadrenalism Ectopic Acth Syndrome Hyperadrenocorticism Cushing Disease Cushing'S Disease Adrenal Cortex Adenoma Corticotroph Pituitary Adenoma Pituitary Corticotroph Micro-Adenoma Pituitary-Dependent Cushing Syndrome Pituitary Acth Hypersecretion Acth Syndrome, Ectopic Acth-Secreting Pituitary Adenoma Adrenal Hyperfunction Resulting From Pituitary Acth Excess Ectopic Adrenocorticotropic Hormone Syndrome Nodular Primary Adrenocortical Dysplasia Pituitary Dependent Cushing Syndrome Pituitary Cushing Syndrome Pituitary-Dependant Cushing Syndrome Pituitary-Dependant Hypercortisolism Pituitary-Dependant Hypercortisolism Disorder Aldosteronism Primary Acth Syndrome Ectopic Adrenal Cushing'S Syndrome Adrenal Cortical Adenoma Cushing Syndrome Nos Cortisol Hypersecretion Corticoadrenal Hypersecretion Cushing Syndrome Secondary To Ectopic Acth-Secretion Ectopic Cushing Syndrome Hypercortisolism Due To Nonpituitary Tumour Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome Idiopathic Aldosteronism Aldosteronism Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia Primary Aldosteronism Due To Adrenal Hyperplasia
Nontoxic Goiter	Goiter, Non-Toxic Goitre, Non-Toxic Nodule-Thyroid, Non Tox Non-Toxic Goitre Non-Toxic Simple Goitre Goitre Nos Goitre Struma Enlarged Thyroid Gland Thyromegaly Thyroid Hypertrophy Thyroid Gland Hypertrophy Thyroid Hyperplasia Thyroid Gland Hyperplasia Swelling Of Thyroid Gland Substernal Thyroid Mass Substernal Goitre Substernal Thyroid Retrosternal Thyroid Struma Sporadic Nodular Struma Struma Of Thyroid Retrosternal Goitre Plunging Goitre Nontoxic Nodular Goitre Nodular Struma Form Of Goitre Hyperplastic Goitre Hypertrophic Thyroid Intrathoracic Goitre Nodular Goitre
Bronchitis	Chronic Bronchitis Acute Bronchitis Bronchitis, Chronic Acute Bronchitis And Bronchiolitis Chest Cold Chest Infection Ci - Chest Infection Recurrent Wheezy Bronchitis Bronchitis Chronic Lower Respiratory Tract Infection Acute Lower Respiratory Tract Infection Chronic Bronchitis Nos Senile Bronchitis Bronchitis Nos In Those Under L5 Years Of Age Bronchitis Nos
Pain Agnosia	Analgesia
Meningitis	Streptococcal Meningitis Acute Streptococcal Meningitis Staphylococcal Meningitis Adenoviral Meningitis Influenza Meningitis Influenzal Meningitis Meningitis Due To H. Influenzae Cryptococcal Meningitis Fungal Meningitis Due To Cryptococcus Neoformans Cryptococcosis Meningitis Cryptococcus Meningitis Cryptococcal Meningoencephalitis Meningitis Due To Cryptococcus Mumps Virus Meningitis Mumps Meningitis
Headache	Headache Disorder
Interstitial Cystitis	Bladder Pain Syndrome Painful Bladder Syndrome Ulcerative Cystitis Ic/Bps Ic/Pbs Interstitial Cystitis/Bladder Pain Syndrome Interstitial Cystitis/Painful Bladder Syndrome Cystitis, Interstitial Chronic Interstitial Cystitis Pelvic Congestion Syndrome Trigonitis
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Detrusor Sphincter Dyssynergia	Detrusor And Sphincter Dyssynergia
Small Cell Cancer Of The Lung	Small Cell Lung Cancer Small Cell Lung Carcinoma Sclc Small-Cell Cancer Of Lung Lung Small Cell Carcinoma Sclc1 Sccl Cancer, Lung, Small Cell Small Cell Carcinoma Of Lung Carcinoma, Small Cell
Neurogenic Arthropathy	Neuropathic Arthropathy Arthropathy Associated With Neurological Disorder Charcot'S Arthropathy Charcot'S Joint Arthropathy, Neurogenic Charcot Joint Charcot Or Tabetic Arthropathy Charcot Foot
Hypervitaminosis D	Vitamin D Hyperalimentation
Thyroid Gland Follicular Carcinoma	Follicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular
Cauda Equina Syndrome	Cauda Equina Polyradiculopathy
Ectopic Thymus
Agnosia	Dyspraxia Primary Visual Agnosia Dyspraxia Syndrome Monomodal Visual Amnesia Visual Amnesia Agnosia, Primary Visual Apraxias Alexia
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Pancreatic Cholera	Excessive Vasoactive Intestinal Peptide Secretion Pancreatic Wdha Syndrome Verner-Morrison Syndrome
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Tooth Resorption
Diabetic Polyneuropathy	Diabetes Mellitus With Polyneuropathy Polyneuropathy In Diabetes Diabetic Polyneuropathies Diabetic Neuropathy Nos
Trigeminal Neuralgia	Tic Douloureux Trifacial Neuralgia Trifocal Neuralgia Neuralgia Of The Fifth Cranial Nerve Neuralgia Of 5th Cranial Nerve Infraorbital Neuralgia
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Endocrine Pancreas Disease	Disorder Of Endocrine Pancreas
Frozen Shoulder	Adhesive Capsulitis Of Shoulder Bursitis Adhesions-Capsulitis,Shoulder Pericapsulitis Of Shoulder Duplay Bursitis Adhesive Shoulder Peritendinitis Subscapular Adhesion Shoulder Adhesion Adhesive Enthesopathy Of Shoulder Region Adhesive Peritendinitis Adhesive Shoulder Tenosynovitis Duplay Periarthritis Adhesive Shoulder Tendinitis
Ischemic Bone Disease
Xanthomatosis	Xanthomatosis, Susceptibility To Xanthelasmatosis
Ectopic Cushing Syndrome	Cushing Syndrome Due To Ectopic Acth Secretion Ectopic Acth Secreting Tumor Adrenocorticotropic Hormone Secretion Syndrome Occult Ectopic Acth Secretion Paraneoplastic Cushing Syndrome
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Glossopharyngeal Neuralgia	Glossopharyngeal Nerve Diseases
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
Glossopharyngeal Nerve Disease	Ninth Cranial Nerve Disease Glossopharyngeal Nerve Diseases Disorders Of The Ninth Cranial Nerve Disorders Of 9th Cranial Nerve
Nerve Compression Syndrome	Entrapment Neuropathies Compression Neuropathy Entrapment Neuropathy Peripheral Nerve Entrapment Syndrome Nerve Compression Syndromes Hereditary Liability To Pressure Palsies
Lateral Medullary Syndrome	Posterior Inferior Cerebellar Artery Syndrome Wallenberg Syndrome Vertebral Artery Syndrome Wallenberg'S Syndrome Pica Syndrome
Hemangioma	Hemangiomas
Bursitis	Bursitis, Not Otherwise Specified Inflammation Of Bursa
Peripheral Nervous System Benign Neoplasm
Autonomic Nervous System Benign Neoplasm
Endocrine Organ Benign Neoplasm
Plummer'S Disease	Toxic Nodular Goiter Plummer Disease Goiter Toxic Nodular
Telangiectatic Osteogenic Sarcoma	Telangiectatic Osteosarcoma
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Hypomagnesemia 6, Renal	Renal Hypomagnesemia 6 HOMG6 Renal Hypomagnesemia-6 Hypomagnesemia 6 Hypomagnesemia, Type 6, Renal
Paralytic Ileus	Adynamic Ileus Paralytic Ileus Of Bowel Ileus Nos Paralysis Of Bowel Paralysis Of Intestine Adynamic Intestinal Obstruction Paralytic Intestinal Ileus
Familial Hemiplegic Migraine	Hemiplegic Migraine, Familial Hemiplegic-Ophthalmoplegic Migraine Fhm Hemiplegic Migraine Familial
Kohler'S Disease	Kohler Disease Aseptic Necrosis Of The Tarsal Bone Osteochondrosis Of The Tarsal Bone Juvenile Osteochondrosis Of Foot Kohler'S Disease Of The Tarsal Navicular Kohler'S Osteochondrosis Of The Tarsal Navicular Navicular Osteochondrosis Obsolete: Osteochondritis Of Tarsal/Metatarsal Bone Osteochondritis Of Tarsal/Metatarsal Bone Avascular Necrosis Of The Tarsal Bone Larsen-Johansson Syndrome
Graves Disease 1	Thyrotoxicosis Graves Disease, Susceptibility To, 1 GRD1 Grd Hyperthyroidism, Autoimmune Hyperthyroidism Hyperactive Thyroid Gland Overactive Thyroid Toxic Diffuse Goitre Toxic Primary Thyroid Hyperplasia Stokes Disease Thyrotoxicosis With Goitre Thyrotoxicosis Struma Graves Disease Goitre With Hyperthyroidism Basedow Disease Exophthalmic Goitre Exophthalmic Struma Flajani Disease Graves Disease With Exophthalmos Hyperthyroid Goitre Hyperthyroidism Struma Thyroid Exophthalmos Malignant Exophthalmos Parry Disease Toxic Diffuse Goitre With Exophthalmos Toxic Goitre Toxic Goitre Nos Thyrotoxicosis Due To Uninodular Goitre Toxic Thyroid Nodule Toxic Uninodular Goitre Uninodular Toxic Struma Uninodular Toxic Struma With Hyperthyroidism Thyrotoxicosis Due To Single Thyroid Nodule Toxic Uninodular Goitre With Hyperthyroidism Hyperthyroidism With Thyroid Nodule Thyrotoxicosis With Toxic Uninodular Goitre Uninodular Goitre In Hyperthyroidism Uninodular Goitre In Thyrotoxicosis Toxic Multinodular Goitre Multinodular Goitre With Thyrotoxicosis Thyrotoxicosis Nodular Goitre Nodular Goitre With Thyrotoxicosis Adenomatous Goitre With Hyperthyroidism Multinodular Goitre With Hyperthyroidism Nodular Goitre With Hyperthyroidism Nodular Struma With Hyperthyroidism Plummer Disease Thyrotoxicosis Adenomatous Goitre Thyrotoxicosis Adenomatous Struma Toxic Adenomatous Goitre Toxic Adenomatous Struma Toxic Nodular Goitre Nos Toxic Struma Nodosa Toxic Nodular Struma
Neurohypophysis Granular Cell Tumor	Granular Cell Tumor Of The Neurohypophysis
Mononeuropathy	Mononeuropathies
Radiculopathy	Pinched Nerve Nerve Root Disorder Radiculopathy, Site Unspecified Radicular Neuropathy Radicular Syndrome Radicular Pain Radiculitis Radiculitis Nos Spinal Root Pain Nerve Root Neuritis Radiculopathy In Spondylosis
Thoracic Outlet Syndrome	Tos Tos - Thoracic Outlet Syndrome Thoracic Outlet Syndromes Thoracic Outlet Compression Syndrome
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Diabetic Neuropathy	Diabetic Neuropathies
Isthmus Cancer
Horner'S Syndrome	Horner Syndrome Bernard-Horner Syndrome Oculosympathetic Palsy Bernard Horner Syndrome Cervical Sympathetic Paralysis Von Passow Syndrome Cervical Sympathetic Dystrophy
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Barre-Lieou Syndrome	Cervicocranial Syndrome Posterior Cervical Sympathetic Syndrome
Thyroid Dyshormonogenesis 2a	TDH2A Iodide Peroxidase Deficiency Deficiency Of Iodide Peroxidase Thyroid Peroxidase Deficiency Genetic Defect In Thyroid Hormonogenesis 2a Thyroid Hormonogenesis, Genetic Defect In, 2a Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2a Chdh2a Congenital Hypothyroidism Due To Dyshormonogenesis Type 2a Thyroid Hormone Organification Defect 2 Tiod
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Keratopathy
Nonencapsulated Sclerosing Carcinoma	Nonencapsulated Sclerosing Neoplasm Papillary Carcinoma, Diffuse Sclerosing
External Ear Carcinoma	Carcinoma Of External Ear Carcinoma Of The External Ear
Neurogenic Bladder	Neurogenic Dysfunction Of The Urinary Bladder Neurogenic Urinary Bladder Disorder Neuropathic Bladder Bladder Neurogenic Urinary Bladder, Neurogenic Neurogenic Urinary Bladder
Spastic Entropion
Perianal Hematoma	External Thrombosed Haemorrhoids Thrombosed External Hemorrhoids
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]
Sublingual Gland Cancer	Malignant Tumor Of Sublingual Gland Malignant Tumor Of The Sublingual Gland
Nasal Cavity Olfactory Neuroblastoma	Olfactory Neuroblastoma Of The Nasal Cavity
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Interval Angle-Closure Glaucoma	Intermittent Angle-Closure Glaucoma Angle-Closure Glaucoma, Subacute Prodromal Angle Closure Glaucoma
Brittle Bone Disorder	Osteogenesis Imperfecta Brittle Bone Disease Fragilitas Ossium Osteopsathyrosis Lobstein Disease Oi Vrolik Disease Lobstein'S Disease Lobstein'S Syndrome Vrolik'S Disease Porak And Durante Disease Glass Bone Disease Osteogenesis Imperfecta, Dominant Perinatal Lethal Osteogenesis Imperfecta, Recessive Perinatal Lethal Brittle Bone Syndrome Oi - [Osteogenesis Imperfecta] Ossium Fragility Osteitis Fragilitans Bony Fragility Blue Sclera With Fragility Of Bone And Deafness White Blue Sclera - Fragility Of Bone - Deafness
Diabetes Mellitus	Diabetes
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Otosclerosis	Otospongiosis
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Patent Foramen Ovale	Atrial Septal Defect Within Oval Fossa Foramen Ovale Patent Ostium Secundum Atrial Septal Defect Atrial Septal Defect, Ostium Secundum Type Foramen Ovale, Patent Defect, Patent Or Persistent, Ostium Secundum Ostium Secundum Type Atrial Septal Defect Persistent Ostium Secundum Asd Ostium Secundum Type Ostium Secundum Asd Osasd Asd, Ostium Secundum Type Pfo - [Patent Foramen Ovale] Open Foramen Ovale Open Oval Foramen Persistent Foramen Ovale Secundum Atrial Septal Defect
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS01828	CALCA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18268	Calca Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24746	Calca Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CALCA	VGNC	VGNC:110499
Mus musculus	CALCA	MGD	MGI:2151253
Rattus norvegicus	CALCA	RGD	RGD:2254
Others	CALCA	NCBI