DCAF6 - DDB1 and CUL4 associated factor 6 Gene

Also Known as NRIP; ARCAP; IQWD1; PC326; MSTP055; 1200006M05Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55827

Summary

The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), Glucocorticoid Receptor (GR), and Androgen Receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of Androgen Receptor in prostate tissues. In addition, this protein can act with Glucocorticoid Receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]
Broad expression in testis (RPKM 48.7), heart (RPKM 45.3) and 24 other tissues.

DCAF6 Products (1)

mRNA Protein Name
NG_053062.2 [RefSeqGene]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
15784617 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16949367 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15784617 GOA
Cellular Component GO Annotation Evidence References Source
part of Cul4-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
16949367 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15784617 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCAF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DCAF6 Q58WW2 GTF2IRD1 Homo sapiens Q9UHL9
Y2H
26275350
Intra
DCAF6 Q58WW2 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
DCAF6 Q58WW2 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
DCAF6 Q58WW2 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (32)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149934 DCAF1 binder 1 99.12% Unkown
HY-W037495 DCAF15 ligand-1 99.32% Unkown
HY-185391 DCAF1 ligand 2 99.89% Unkown
HY-156743 DCAF1 binder 2 / Unkown
HY-169151 PROTAC BRD4-DCAF1 degrader-1 / Unkown
HY-169152 DCAF1 ligand 1 / Unkown
HY-181757 DCAF11 ligand-Linker Conjugate 1 Control / Unkown
HY-32247 DCAF 99.65% Unkown
HY-RS03557 DCAF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03558 DCAF11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03559 DCAF12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03560 DCAF13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03561 DCAF15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03562 DCAF16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03563 DCAF17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03564 DCAF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03565 DCAF4L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03566 DCAF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03567 DCAF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03568 DCAF8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W288798 DCAF11 ligand 2 / Unkown
HY-W957284 DCAF11 ligand 1 / Unkown
HY-182974 DCAF1 binder 3 / Unkown
HY-RS18306 Dcaf15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20389 Dcaf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20901 Dcaf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22465 Dcaf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23600 Dcaf16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24784 Dcaf15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26898 Dcaf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27418 Dcaf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28988 Dcaf4 Rat Pre-designed siRNA Set A / Unkown