CD276 - CD276 molecule Gene

Also Known as B7H3; B7-H3; B7RP-2; 4Ig-B7-H3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80381

About CD276

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:73,683,944-73,714,514 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 15 paralogues. Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 MicroRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

CD276 Products (4)

mRNA Protein Name
NM_001024736.2 NP_001019907.1 CD276 antigen isoform a precursor
NM_001329628.2 NP_001316557.1 CD276 antigen isoform b precursor
NM_001329629.2 NP_001316558.1 CD276 antigen isoform c
NM_025240.3 NP_079516.1 CD276 antigen isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
18650384 GOA
Biological Process GO Annotation Evidence Références Source
involved in T cell activation IDA
IDA: Inferred from direct assay
18650384 GOA
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
11224528 GOA
involved in positive regulation of type II interferon production IDA
IDA: Inferred from direct assay
11224528 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CD276 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (30 - 127)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (148 - 228)

V-set

V-set: Immunoglobulin V-set domain (247 - 345)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (366 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

CD276 antigen

  • B7 homolog 3

Recombinant CD276 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P7326 CD276/B7-H3 Protein, Human (HEK293, Fc) Q5ZPR3-2 (L29-P245) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7327 CD276/B7-H3 Protein, Human (HEK293, His) Q5ZPR3-2 (L29-P245) ≥ 95%, as determined by reducing SDS-PAGE or Bis-Tris PAGE.
HY-P70652 CD276/B7-H3 (4Ig)/B7-H3b Protein, Human (HEK293, His) Q5ZPR3-1 (L29-T461) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74317 CD276/B7-H3 (4Ig)/B7-H3b Protein, Human (HEK293, hFc) Q5ZPR3-1 (L29-T461) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77538 CD276/B7-H3 (4Ig)/B7-H3b Protein, Human (Biotinylated, HEK293, His) Q5ZPR3-1 (L29-T461) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78074 CD276/B7-H3 (4Ig)/B7-H3b Protein, Human (Biotinylated, HEK293, His-Avi) Q5ZPR3-1 (G27-T461) ≥ 95%, as determined by Bis-Tris PAGE.
HY-P78930 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, Fc-Avi) Q5ZPR3-2 (L29-P245) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700448 CD276/B7-H3 (4Ig)/B7-H3b Protein, Human (217a.a, HEK293, Myc-hFc) Q5ZPR3-1 (L29-G245) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700880 CD276/B7-H3 Protein, Human (Biotinylated, HEK293, C-His-Avi) Q5ZPR3-2 (L29-P245) ≥ 95%, as determined by reducing SDS-PAGE.

CD276 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81534 CD276 Antibody (YA1279) IHC-P Human
HY-P81534A CD276 Antibody (YA1279)(PBS only) IHC-P Human
HY-P84637 CD276/B7H3 Antibody (YA4334) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat, Rabbit, Monkey
HY-P84637A CD276/B7H3 Antibody (YA4334)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human, Mouse, Rat, Rabbit, Monkey
HY-P84983 CD276/B7H3 Antibody (YA4675) ELISA Human
HY-P85087 CD276/B7H3 Antibody (YA4779) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P85833 CD276/B7H3 Antibody (YA5525) WB, ICC/IF, ELISA Human, Mouse, Rat

Related Diseases

Diseases Alias
Immunodeficiency 16

  • Combined Immunodeficiency Due To Ox40 Deficiency

  • IMD16

  • Ox40 Deficiency

  • Combined Immunodeficiency With Childhood-Onset Kaposi Sarcoma

  • Combined Immunodeficiency With Impaired Immunity To Hhv-8

  • Combined Immunodeficiency With Impaired Immunity To Human Herpes Virus 8

  • Immunodeficiency, Type 16
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Craniopharyngioma

  • Neoplasm Of Rathke'S Pouch

  • Adamantinomatous Tumor

  • Craniopharyngeal Duct Tumor

  • Dysodontogenic Epithelial Tumor

  • Rathke'S Pouch Tumor
Autoimmune Peripheral Neuropathy
Central Nervous System Neuroblastoma
Rhabdomyosarcoma
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Co-Trimoxazole Allergy

  • Bactrim Allergy

  • Cotrimoxazol Allergy

  • Tmp/Smx Allergy

  • Trimethoprim/Sulfamethoxazole Allergy
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Nervous System Disease

  • Abnormality Of The Nervous System

  • Nervous System Diseases

  • Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P99157 Omburtamab Inhibitor 99.16% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-145636 Vobramitamab duocarmazine 99.31% Unkown
HY-RS02220 CD276 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17006 Cd276 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23449 Cd276 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990279 Anti-Mouse CD276/B7-H3 Antibody (MJ18) 95.00% Unkown
HY-P99740 Mirzotamab Inhibitor 99.45% Unkown
HY-P992110 Elfetabart Inhibitor 98.31% Unkown
HY-P992158 VBI-009 / Unkown
HY-P990340 Anti-B7-H3/CD276 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CD276 RGD RGD:727815
Canis familiaris CD276 VGNC VGNC:38943
Felis catus CD276 VGNC VGNC:60603
Bos taurus CD276 VGNC VGNC:27020
Mus musculus CD276 MGD MGI:2183926
Macaca mulatta CD276 VGNC VGNC:70826
Others CD276 NCBI