NMT2 - N-myristoyltransferase 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9397

About NMT2

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:15,105,700-15,168,693 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 9.3), testis (RPKM 5.5) and 24 other tissues.

Summary

This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

NMT2 Products (2)

mRNA Protein Name
NM_001308295.2 NP_001295224.1 glycylpeptide N-tetradecanoyltransferase 2 isoform 2
NM_004808.3 NP_004799.1 glycylpeptide N-tetradecanoyltransferase 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables glycylpeptide N-tetradecanoyltransferase activity IDA
IDA: Inferred from direct assay
25255805 GOA
enables peptidyl-lysine N6-myristoyltransferase activity IDA
IDA: Inferred from direct assay
32103017 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16530191 GOA
Biological Process GO Annotation Evidence Références Source
involved in N-terminal peptidyl-glycine N-myristoylation IDA
IDA: Inferred from direct assay
25255805 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9506952 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
9506952 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NMT2 Protein Structure

NMT

NMT: Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain (143 - 296)

NMT_C

NMT_C: Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain (310 - 497)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 498 a.a.
Protein Preferred Names Protein Names

glycylpeptide N-tetradecanoyltransferase 2

  • NMT 2

NMT2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NMT2 O60551 BTF3 Homo sapiens P20290-2
Validated Y2H
32296183
Intra
NMT2 O60551 ACBD6 Homo sapiens Q9BR61
Validated Y2H
32296183
Intra
NMT2 O60551 ACBD6 Homo sapiens Q9BR61
Y2H Array
32296183
Intra
NMT2 O60551 ACBD6 Homo sapiens Q9BR61
Myristoylase Assay
26621918
Intra
NMT2 O60551 ACBD6 Homo sapiens Q9BR61
Anti Tag CoIP
26621918
Intra
NMT2 O60551 ACBD6 Homo sapiens Q9BR61
Crosslink
26621918
Intra
NMT2 O60551 ACBD6 Homo sapiens Q9BR61
Y2H Prey Pooling
32296183
Intra
NMT2 O60551 CASP3 Homo sapiens P42574
Anti Bait CoIP
16530191
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-112258 IMP-1088 Inhibitor 98.84% Unkown
HY-147308 Zelenirstat Inhibitor 99.76% Unkown
HY-P6028A GSNKSKPK-NH2 TFA Substrate 99.91% Unkown
HY-P6028 GSNKSKPK-NH2 Substrate 98.00% Unkown
HY-RS09390 NMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18145 Nmt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24620 Nmt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NMT2 MGD MGI:1202298
Canis familiaris NMT2 VGNC VGNC:52219
Rattus norvegicus NMT2 RGD RGD:1303175
Felis catus NMT2 VGNC VGNC:68508
Macaca mulatta NMT2 VGNC VGNC:75361
Bos taurus NMT2 VGNC VGNC:32138
Others NMT2 NCBI